Back to results
US 4,411,899 AGranted
Substituted derivatives of amino alkane diols as gastric secretion inhibitors
AssigneeMerck & Co., Inc.
InventorsJohn J. Baldwin, William C. Lumma, Jr.
Life of this patent
Estimating the term…
Abstract
There are disclosed substituted derivatives of amino alkane diols and related compounds as well as processes for the preparation of such compounds. These compounds are useful for the suppression of gastric acid secretions in mammals and compositions for such uses are also disclosed.
Claims12
A compound having the formula:
- ##STR9## wherein R.sup.1 is hydrogen, loweralkyl;
- R.sup.2 is hydrogen, loweralkyl, benzyl, loweralkanoyl, loweralkyoxyloweralkyl, benzyloxyloweralkyl;
- R.sup.3 and R.sup.4 are independently hydrogen, loweralkyl, cycloloweralkyl of C.sub.3 -C.sub.8, cycloalkylalkyl of C.sub.3 -C.sub.8, or R.sup.3 and R.sup.4 may be joined to form, together with the nitrogen to which they are attached, --(CH.sub.2).sub.r X(CH.sub.2).sub.r' -- wherein X can be O, S, CH.sub.2, or NR.sup.5 wherein R.sup.5 is hydrogen, loweralkyl;
- loweralkanoyl;
- r and r' are independently 1, 2, or 3 provided that when r or r' is 1, X is CH.sub.2 ;
- n is 1 or 2;
- m is 1 or 2;
- k is 0 to 4;
- A is a substituted phenylene wherein the substituent can be hydrogen, halo, cyano, loweralkoxy, loweralkyl;
- E is ##STR10## wherein R.sup.7 is hydrogen, loweralkyl, substituted loweralkyl wherein the substituent can be hydroxy, alkoxy;
- loweralkynyl;
- loweralkenyl or loweralkanoyl;
- aryl;
- substituted aryl wherein the substituent can be halo, loweralkoxy, loweralkyl;
- heteroaryl;
- p is 1 or 2;
- and,
- the physiologically acceptable, non-toxic salts thereof.
15 more elements
Dependencies are inferred from the claim text.