Loading patent…
OwnerSteven R. Jefferies, James L. Gutmann +1inventors
InventorsSteven R. Jefferies, James L. Gutmann, Barry M. Heatfield
Estimating the term…
Collagen polymers are rendered non-inflammatory by complexation with alkaline phosphatase according to the procedure disclosed. Applications of these non-inflammatory collagen complexes include the production of non-inflammatory collagen sutures, collagen soft tissue replacements including wound and burn coverings and arterial vessel replacements, collagen drug delivery devices, and vitreous replacement for opthalmologic therapy. Gels composed of the collagen-alkaline phosphatase conjugate plus calcium hydroxide are useful as an agent in endodontic therapy. Structural durability and stabilization of the anti-inflammatory properties of the material are enhanced by crosslinking with glutaraldehyde or other crosslinking agents. Glutaraldehyde also acts to sterilize and disinfect the collagen conjugate prior to in-vivo use.
An inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with soluble alkaline phosphatase.
An article of manufacture consisting essentially of an inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with soluble alkaline phosphatase.
A drug delivery support consisting essentially of an inert, non-inflammatory polymeric conjugate of reconstituted collagen crosslinked to form a matrix and complexed with a soluble alkaline phosphatase and at least one drug substance compatible with and adapted to separate from said conjugate over a period of several days.
A method of forming a collagen-phosphatase conjugate comprising treating a collagen matrix with a solution of soluble alkaline phosphatase until an inert, non-inflammatory a collagen-phosphatase conjugate is formed.
Dependencies are inferred from the claim text.