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US 4,409,217 AGranted
Cephem compounds
AssigneeFujisawa Pharmaceutical Co., Ltd.
InventorsTakao Takaya, Hisashi Takasugi, Toshiyuki Chiba, Kiyoshi Tsuji
Life of this patent
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Abstract
The invention relates to new cephem compounds, of high antimicrobial activity of the formula: ##STR1## wherein R.sup.1 is amino or protected amino, R.sup.2 is carboxy(lower)alkyl or protected carboxy(lower)alkyl, R.sup.3 is halogen or lower alkoxy, and R.sup.4 is carboxy or protected carboxy, and a pharmaceutically acceptable salt thereof.
Claims3
A compound selected from the group consisting of:
- 4-nitrobenzyl 7-[2-(tert-butoxycarbonylmethoxyimino)-2-(2-formamidothiazol-4-yl)acetamid o]-3-chloro-3-cephem-4-carboxylate (syn isomer),
- 7-[2-(tert-butoxycarbonylmethoxyimino-2-(2-formamidothiazol-4-yl)-acetamido ]-3-chloro-3-cephem-4-carboxylic acid (syn isomer),
- 7-[2-(tert-butoxycarbonylmethoxyimino)-2-(2-aminothiazol-4-yl)-acetamino]-3 -chloro-3-cephem-4-carboxylic acid (syn isomer), and
- 7-[2-carboxymethoxyimino-2-(2-aminothiazol-4-yl)acetamido]-3-chloro-3-cephe m-4-carboxylic acid (syn isomer).
1 more element
Dependencies are inferred from the claim text.