Novel phenylacetic acid derivatives
AssigneeSchering Corporation
InventorsGerald Kirsch, Joachim-Friedrich Kapp, Clemens Rufer
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Abstract
Phenylacetic acid derivatives of the formula ##STR1## wherein n is an integer of 2 to 5; ##STR2## R.sub.1 is hydrogen, halogen, trifluoromethyl, nitro or amino; R.sub.2 and R.sub.3 each independently is hydrogen or lower alkyl; or together form an ethylene group; X.sub.1 represents two hydrogen atoms or an oxo group; and Y.sub.1 is cyano, hydroxyamidocarbonyl, carbamoyl, 5-tetrazolyl or carboxyl; and for derivatives wherein Y is carboxyl, salts thereof with physiologically compatible bases, esters thereof from physiologically acceptable alcohols and amides thereof from physiologically acceptable amines have valuable pharmacological activity, e.g., as antiinflammatory agents.
Claims9
A phenylacetic acid compound of the formula ##STR30## wherein n is an integer of 2 to 5;
- ##STR31## R.sub.1 is hydrogen, halogen, trifluoromethyl, nitro or amino;
- X.sub.1 represents two hydrogen atoms or an oxo group;
- and
- Y.sub.1 is carboxyl or a physiologically compatible salt thereof with a base, or ester thereof from a physiologically acceptable alcohol.
Dependencies are inferred from the claim text.