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US 4,407,816 AGranted
3-Substituted-2-propenimidamides and method of manufacturing the same
AssigneeKotobuki Seiyaku Co., Ltd.
InventorsTsuyoshi Tomiyama, Akira Tomiyama
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Abstract
New derivatives of 3-furyl-, 3-thienyl- and 3-phenyl-2-propenimidamides are disclosed, which are useful as anti-ulcer agents. These new compounds are synthesized by reacting an imino ether derived from a corresponding 3-substituted-2-propenenitrile with a suitable amine.
Claims13
A compound of the formula:
- ##STR40## wherein:
- A is a furyl, thienyl, phenyl, chlorophenyl or lower-alkoxyphenyl group;
- R.sup.1 represents .dbd.NCN or .dbd.NCONH.sub.2 and
- R.sup.2 represents --NHR.sup.3 or --NHNHCOR.sup.4, wherein R.sup.3 is a hydrogen atom, or a lower-alkyl, phen-lower-alkyl or cyclohexyl group, said cyclohexyl group being optionally substituted by lower-alkyl and R.sup.4 is a lower alkyl group, and
- pharmaceutically acceptable acid addition salts thereof.
2 more elements
Dependencies are inferred from the claim text.