2-Pyridyl-2-thiazoline-4-carboxylic acid derivatives
AssigneeCiba-Geigy Corporation
InventorsHans Zahner, Hans-Ulrich Naegeli, Heinrich Peter
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AssigneeCiba-Geigy Corporation
InventorsHans Zahner, Hans-Ulrich Naegeli, Heinrich Peter
Estimating the term…
The invention relates especially to 2-(3'-hydroxypyrid-2'-yl)-2-thiazoline-4-carboxylic acid derivatives of the formula (I) and salts and also certain metal complexes of these compounds, processes for their manufacture, pharmaceutical agents containing such compounds and the use of these compounds. ##STR1## In the formula, R.sup.1 represents free, etherified or esterified hydroxy, R.sup.2 represents hydrogen or an aliphatic, carbocyclic or carbocyclic-aliphatic radical having 1-12 carbon atoms, and R.sup.3 represents hydrogen or an unsubstituted aliphatic radical having 1-7 carbon atoms. The compounds of the formula (I) can be used, for example, for the abstraction of heavy metals from the organism of warm-blooded animals and/or they have an antibiotic action.
A 2-(3'hydroxy-pyrid-2'-yl)-2-thiazoline-4-carboxylic acid derivative of the formula ##STR7## in a racemic or optically active form, in which R.sub.1 represents free hydroxy, hydrocarbyloxy, hydrocarbylcarbonyloxy or hydrocarbyloxycarbonyloxy, hydrocarbyl denoting an aliphatic radical having 1-7 carbon atoms, a cycloaliphatic radical having 3 to 8 ring members, a phenyl radical, or an aliphatic radical having 1-7 carbon atoms that is substituted by at least one cycloaliphatic radical having 3 to 8 ring members or by at least one phenyl radical, or in which R.sup.1 represents monocyclic aromatic or lower aliphatic sulphonyloxy;
Dependencies are inferred from the claim text.