Preparation of native oncornavirus envelope subunits and vaccines therefrom
AssigneeResearch Corporation
InventorAbraham Pinter
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Abstract
Non-denatured [gp90] is isolated from oncornavirus envelopes including feline and murine leukemia virus envelopes and utilized as vaccines. The materials as isolated may be used directly on in various compositions.
Claims5
A non-denatured glycoprotein, [gp90] having a molecular weight of 90,000 daltons, comprised of units of gp70 and p15 (E), capable of immunoprecipitation with anti-gp70 sera and anti-p15 (E) sera, yielding gp70 and p15 (E) upon reduction with mercaptoethanol, which is aqueous solution in the presence of nonionic detergents exists as a complex with a molecular weight of 360,000 to 450,000.
A vaccine to protect cats against infection by feline leukemia virus containing the glycoprotein [gp90] as its principal active ingredient.
A method for protecting cats against disease caused by feline leukemia virus which comprises administering to a cat a vaccine containing the glycoprotein [gp90].
Dependencies are inferred from the claim text.