US 4,401,827 AGranted

Novel acyl-derivatives of carnitine and process for their preparation

AssigneeSigma-Tau

InventorPaolo de Witt

Life of this patent

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Abstract

Novel acyl-derivatives of the .beta.-hydroxy-.gamma.-butyrobetaine are disclosed (typically pyruvyl carnitine hydrochloride) which are useful therapeutic agents in the treatment of cardiac disorders, hyperlipidoemias and hyperlipoproteinemias.

Claims5

Dependent claims

Acyl derivatives of carnitine having the general formula:

##STR23## wherein R is the monovalent radical of the following organic acids:
3-bromopropionic, 4-chorobutyric, cyclohexylcarboxylic, cyclohexylpropionic, .alpha.-methylenebutyric, .beta.-methylenebutyric, cinnamic, p-methylcinnamic, p-chlorocinnamic, p-methoxycinnamic, m-trifluoromethylcinnamic, m-bromocinnamic, phenylacetic, p-isobutylphenylacetic, p-methylphenylacetic, p-ethylphenylacetic, p-cyclohexylphenylacetic, p-cyclopropylphenylacetic, p-isobutyl m-chlorophenylacetic, .alpha.-phenylpropionic, p-isobutyl, .alpha.-phenylpropionic, p-methyl, .alpha.-phenylpropionic, p-ethyl .alpha.-phenylpropionic, p-cyclohexyl .alpha.-phenylpropionic, p-cyclopropyl .alpha.-phenylpropionic, p-isobutyl .alpha.-phenylpropionic, 2-naphthalene acetic, malonic (monoester), glutaric (monoester), .alpha.-methylglutaric (monoester), adipic (monoester), pimelic (monoester), suberic (monoester), azelaic (monoester), sebacic (monoester), .alpha.-methyl-.alpha.-hydroxy glutaric (monoester), fumaric (monoester), citric (monoester), isocitric (monoester), pyruvic, levulinic, .alpha.-ketoglutaric (monoester), .beta.-ketoglutaric (monoester), oxalacetic, .gamma.N-acetylaminobutric, .epsilon.N-acetylaminocaproic, N-acetylaspartic (monoester), N-acetylglutamic (monoester), N-acetyl-5 aminoglutamic (monoester), N-acetylcysteine, S, N-diacetylcysteine, N-acetyl leucine, N-acetyl isolelucine, N-acetylmethionine, and N-acetylvaline.

Dependencies are inferred from the claim text.

Facts

Application: 06/334,604Filed 28 Dec 1981 · continuation
Priority: IT 50065 A/7827 Jun 1978
Granted: 30 Aug 1983
Term ends: Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07C 229/22
The carbon skeleton being acyclic and saturated: the carbon skeleton being further substituted by oxygen atoms
A61P 7/00
Drugs for disorders of the blood or the extracellular fluid
C07C 233/47
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…
C07C 237/12
The carbon skeleton being acyclic and saturated: having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon…

Family

Serial52,283Parent of this continuation · filed 26 Jun 1979
US 4,401,827 AThis patent

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Abstract

Facts

Application

06/334,604Filed 28 Dec 1981 · continuation

Priority

IT 50065 A/7827 Jun 1978

Granted

30 Aug 1983

Term ends

Not estimatedThe source records don’t support an estimate.

Classification7 codes

C07C 229/22
The carbon skeleton being acyclic and saturated: the carbon skeleton being further substituted by oxygen atoms
A61P 7/00
Drugs for disorders of the blood or the extracellular fluid
C07C 233/47
With the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by an acyclic carbon atom: having the carbon atom of…
C07C 237/12
The carbon skeleton being acyclic and saturated: having the nitrogen atom of at least one of the carboxamide groups bound to an acyclic carbon…