# US 4,400,534 A · Analgesic and anti-inflammatory agents

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- Number: US 4,400,534 A
- Document ID: US4400534A
- Status: Granted
- Kind: A
- Application number: 06/331,616
- Filed: 1981-12-17
- Granted: 1983-08-23
- Earliest claimed: 1980-12-23
- Assignees: Sankyo Company, Limited
- Inventors: Atsusuke Terada; Eiichi Misaka
- Web page: https://patentgrep.com/patent/US4400534A

## CPC

- C07C 59/54: containing six-membered aromatic rings and other rings
- A61P 25/04: Centrally acting analgesics, e.g. opioids
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- C07C 51/487: by treatment giving rise to chemical modification (by chemisorption C07C51/47)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Compounds of formula (I): ##STR1## its salts, and resolved forms thereof, especially the compound of formula (II): ##STR2## and its salts are new analgesic and/or anti-inflammatory agents. The agents are prepared by resolution at the 2-position of a suitable starting material such as the compound (IV): ##STR3## or an optionally partly resolved form thereof, with subsequent reduction and optional resolution to give the trans form.

## Claims

### Claim 1

(2S)-2-[4-(2-hydroxycyclopentan-1-ylmethyl)phenyl]propionic acid of the formula (I): ##STR8## or a pharmaceutically active salt thereof.

### Claim 2 (depends on 1)

The acid of claim 1 or a salt thereof, wherein the 1" and 2"-substituents are in trans relationship.

### Claim 3

(2S)-2-{4-[(2S,1R)-2-hydroxycyclopentan-1-ylmethyl[phenyl}propionic acid of the formula (II): ##STR9## or a pharmaceutically active salt thereof.

### Claim 4 (depends on 1, 2, 3)

A pharmaceutical composition comprising an acid or salt according to any of claims 1, 2 and 3, together with a pharmaceutically acceptable vehicle.

### Claim 5 (depends on 3)

A pharmaceutical composition formulated for oral, rectal or topical administration and comprising the acid or salt thereof of claim 3.