# US 4,400,510 A · A-32256 Phenazine antibiotic

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- Number: US 4,400,510 A
- Document ID: US4400510A
- Status: Granted
- Kind: A
- Application number: 06/304,293
- Filed: 1981-09-21
- Granted: 1983-08-23
- Earliest claimed: 1980-04-28
- Assignees: Eli Lilly and Company
- Inventors: Karl H. Michel; Marvin M. Hoehn
- Web page: https://patentgrep.com/patent/US4400510A

## CPC

- C07D 241/46: Phenazines
- C12P 17/12: containing a six-membered hetero ring
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}

## Abstract

Antibiotic A-32256 which is produced by submerged, aerobic fermentation of a Streptomyces sp. NRRL 12067. The antibiotic has shown antibacterial activity against Staphylococcus and Streptococcus and various anaerobic species. In addition, the antibiotic has shown antitrichomonas activity in vitro, as well as activity for improving ruminant feed efficency and as a mosquito larvacide.

## Claims

### Claim 1

Antibiotic A-32256, a compound of the formula ##STR2##

### Claim 2

The compound identified as 6-[1-[(2-hydroxy-6-methylbenzoyl)oxy]ethyl]-1-phenazinecarboxylic acid, disodium salt, monohydrate.