# US 4,400,386 A · Antimicrobial derivatives of 8-amino and 8-aminomethyl benzo(ij)quinolizine

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- Number: US 4,400,386 A
- Document ID: US4400386A
- Status: Granted
- Kind: A
- Application number: 06/318,930
- Filed: 1981-11-06
- Granted: 1983-08-23
- Earliest claimed: 1981-11-06
- Assignees: Riker Laboratories, Inc.
- Inventors: Richard M. Stern
- Web page: https://patentgrep.com/patent/US4400386A

## CPC

- C07D 215/48: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- A61P 31/04: Antibacterial agents
- C07D 215/18: Halogen atoms or nitro radicals
- C07D 215/38: Nitrogen atoms (nitro radicals C07D215/18)
- C07D 455/04: containing a quinolizine ring system condensed with only one six-membered carbocyclic ring, e.g. julolidine
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

This invention relates to antimicrobial compounds of the formula ##STR1## wherein X is hydrogen or fluorine; Y is selected from the group consisting of ##STR2## and ester, carboxylate salts, and alkylaminoalkyl ester salts thereof.

## Claims

### Claim 1

A compound of the formula ##STR17## wherein X is hydrogen or fluorine; Y is selected from the group consisting of ##STR18## or an alkyl or aminoalkyl ester thereof having one to four carbon atoms in the alkyl group, an aminoalkyl ester salt thereof having one to four carbon atoms in the alkyl group or a pharmaceutically-acceptable carboxylate salt thereof.

### Claim 2 (depends on 1)

The compound according to claim 1 selected from the group consisting of (1) where X is hydrogen and Y is ##STR19## (2) where X is hydrogen and Y is --CH.sub.2 NH.sub.2 ; (3) where X is hydrogen and Y is ##STR20## (4) where X is fluoro and Y is ##STR21## (5) where X is fluoro and Y is ##STR22## and (6) where X is hydrogen and Y is --CH.sub.2 N(CH.sub.3).sub.2.

### Claim 3 (depends on 1, 2)

The compound according to claims 1 or 2 which is a carboxylic acid.

### Claim 4 (depends on 1, 2)

A composition for inhibiting the growth of microorganisms comprising an effective amount of a compound according to claims 1 or 2 formulated in a pharmaceutically-acceptable vehicle.

### Claim 5 (depends on 1, 2)

A method of inhibiting the growth of microorganisms comprising contacting said microorganisms with an effective amount of a compound according to claims 1 or 2.