# US 4,400,358 A · Method and adsorbant composition for .sup.82 Rb generation

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- Number: US 4,400,358 A
- Document ID: US4400358A
- Status: Granted
- Kind: A
- Application number: 06/208,918
- Filed: 1980-11-21
- Granted: 1983-08-23
- Earliest claimed: 1980-06-25
- Assignees: E. R. Squibb & Sons, Inc.
- Inventors: Rudi D. Neirinckx
- Web page: https://patentgrep.com/patent/US4400358A

## CPC

- G21G 1/04: outside nuclear reactors or particle accelerators
- G21G: CONVERSION OF CHEMICAL ELEMENTS; RADIOACTIVE SOURCES (applications of radiation in general G21H5/00; handling particles, e.g. neutrons, or electromagnetic radiation not otherwise provided for G21K)

## Abstract

A composition comprising .sup.82 Sr and an adsorbant selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, titanium oxide, and ferric oxide. A low .sup.82 Sr breakthrough method of generating .sup.82 Rb from a .sup.82 Sr charged adsorbant comprising eluting wherein said adsorbant is selected from the group consisting of tin oxide, polyantimonic acid, titanium oxide, ferric oxide, and hydrated tin oxide.

## Claims

### Claim 1

A composition comprising .sup.82 Sr and an adsorbant selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, titanium oxide, ferric oxide, hydrated ferric oxide and hydrated titanium oxide.

### Claim 2 (depends on 1)

The composition of claim 1 wherein said adsorbant is selected from the group consisting of hydrated tin oxide and polyantimonic acid.

### Claim 3 (depends on 1)

The composition of claim 1 wherein said adsorbant comprises chromatotographic particles, said particles comprising hydrated tin oxide.

### Claim 4 (depends on 3)

The composition of claim 3 wherein said .sup.82 Sr is adsorbed on said adsorbant chromatographic particles, said particles having an average diameter of 0.01 to 0.9 mm.

### Claim 5 (depends on 4)

Apparatus for generating .sup.82 Rb comprising container means and the composition of claim 4 contained within said container means, said particles having an average diameter of 0.05 to 0.1 mm.

### Claim 6

A low .sup.82 Sr breakthrough method of generating .sup.82 Rb from a .sup.82 Sr charged adsorbant comprising eluting the .sup.82 Rb from said adsorbant with an eluant solution wherein said adsorbant is selected from the group consisting of tin oxide, hydrated tin oxide, polyantimonic acid, hydrated titanium oxide, and hydrated ferric oxide.

### Claim 7 (depends on 6)

The method of claim 6 wherein said adsorbant is selected from the group consisting of tin oxide, hydrated tin oxide, and polyantimonic acid.

### Claim 8 (depends on 7)

The method of claim 7 further comprising providing container means and containing said .sup.82 Sr charged adsorbant in said container means, said adsorbant comprising chromatographic particles having an average diameter of 0.01 to 0.9 mm.

### Claim 9 (depends on 8)

The method of claim 8 wherein said eluant solution comprises isotonic saline.

### Claim 10 (depends on 9)

The method of claim 9 wherein said eluant solution further comprises a pharmaceutically acceptable buffer.

### Claim 11 (depends on 10)

The method of claim 10 wherein said buffer comprises a phosphate salt or a carbonate salt.

### Claim 12 (depends on 3)

The composition of claim 3 wherein said hydrated tin oxide is a substantial amount of hydrated stannic oxide.

### Claim 13 (depends on 12)

The composition of claim 12 further comprising tin oxide, said composition being amorphous.