# US 4,399,296 A · Hypoglycemic 5-substituted oxazolidine-2,4-diones

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- Number: US 4,399,296 A
- Document ID: US4399296A
- Status: Granted
- Kind: A
- Application number: 06/353,742
- Filed: 1982-03-01
- Granted: 1983-08-16
- Earliest claimed: 1980-07-28
- Assignees: Pfizer Inc.
- Inventors: Rodney C. Schnur
- Web page: https://patentgrep.com/patent/US4399296A

## CPC

- C07C 45/513: {the singly bound functional group being an etherified hydroxyl group}
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Hypoglycemic 5-phenyl and 5-naphthyl oxazolidine-2,4-diones and the pharmaceutically-acceptable salts thereof; certain 3-acylated derivatives thereof; a method of treating hyperglycemic animals therewith; and intermediates useful in the preparation of said compounds.

## Claims

### Claim 1

A compound of the formula ##STR22## wherein R.sup.4 is ##STR23## W is hydrogen or fluoro; W.sup.1 is benzyloxy, chloro, phenoxy, nitro or trifluoromethyl;
W.sup.2 is benzyloxy, phenoxy, nitro or trifluoromethyl;
W.sup.3 is methyl, (C.sub.1 -C.sub.2)alkoxy, methylthio, chloro, or fluoro; and
W.sup.4 and W.sup.5 are each independently hydrogen, methyl, bromo, chloro, fluoro, cyano, nitro or trifluoromethyl.

### Claim 2 (depends on 1)

A compound of claim 1 wherein R.sup.4 is ##STR24## W.sup.2 is fluoro; W.sup.3 is (C.sub.1 -C.sub.2)alkoxy and W.sup.5 is hydrogen, methyl, bromo, chloro, fluoro or cyano.

### Claim 3 (depends on 1)

The compound of claim 1 wherein R.sup.4 is ##STR25##

### Claim 4 (depends on 1)

The compound of claim 1 wherein R.sup.4 is ##STR26##

### Claim 5 (depends on 1)

The compound of claim 1 wherein R.sup.4 is ##STR27##

### Claim 6 (depends on 1)

The compound of claim 1 wherein R.sup.4 is ##STR28##

### Claim 7 (depends on 1)

The compound of claim 1 wherein R.sup.4 is ##STR29##

### Claim 8 (depends on 1)

The compound of claim 1 wherein R.sup.4 is ##STR30##