# US 4,399,293 A · Process for the preparation of a furan derivative

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- Number: US 4,399,293 A
- Document ID: US4399293A
- Status: Granted
- Kind: A
- Application number: 06/350,414
- Filed: 1982-02-19
- Granted: 1983-08-16
- Earliest claimed: 1981-02-20
- Assignees: Glaxo Group Limited
- Inventors: John W. Clitherow
- Web page: https://patentgrep.com/patent/US4399293A

## CPC

- C07D 307/52: Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Ranitidine is prepared by reacting a compound of formula (II) ##STR1## with aziridine. The reaction may be carried out in the absence of a solvent or preferably in the presence of a solvent such as water or an alkanol at elevated temperature.

## Claims

### Claim 1

A process for the preparation of ranitidine of formula (I) ##STR6## which comprises reacting a compound of formula (II) ##STR7## with aziridine.

### Claim 2 (depends on 1)

A process as claimed in claim 1 carried out in the presence of a suitable solvent.

### Claim 3 (depends on 3)

A process as claimed in claim 3 in which the solvent is water or an alkanol.

### Claim 4 (depends on 1)

A process as claimed in claim 1 carried out at a temperature in the range 20.degree. to 100.degree. C.

### Claim 5 (depends on 1)

A process as claimed in claim 1 carried out at a temperature in the range 60.degree. to 100.degree. C.

### Claim 6 (depends on 1)

A process as claimed in claim 1 in which the compounds of formula (I) is converted into an acid addition salt.

### Claim 7 (depends on 6)

A process as claimed in claim 6 in which the acid addition salt is the hydrochloride.

### Claim 8

The compound 1-[[5-[(dimethylamino)methyl]-2-furanylmethyl]thio]-N-methyl-2-nitroethena mine of formula (II) ##STR8##