# US 4,399,286 A · Antiarrhythmic phenethylpiperidine compounds

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- Number: US 4,399,286 A
- Document ID: US4399286A
- Status: Granted
- Kind: A
- Application number: 06/283,710
- Filed: 1981-07-16
- Granted: 1983-08-16
- Earliest claimed: 1981-07-16
- Assignees: Mead Johnson & Company
- Inventors: John E. Lawson
- Web page: https://patentgrep.com/patent/US4399286A

## CPC

- C07D 211/26: with hydrocarbon radicals, substituted by nitrogen atoms
- A61P 9/06: Antiarrhythmics
- A61P 29/00: Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

2-Phenethylpiperidines bearing urea, thiourea, and amidine substituents in the ortho-position of the phenethyl moiety have been synthesized and demonstrate useful antiarrhythmic properties. These novel compounds are prepared by reaction of appropriately substituted o-amino-phenethylpiperidines with appropriately substituted phenyl isothiocyanates, phenyl isocyanates, or phenyl imino esters.

## Claims

### Claim 1

A compound selected from the group consisting of a compound having Formula (I) ##STR23## or a pharmaceutically acceptable salt thereof wherein R.sup.1 is hydrogen, halogen, lower (meaning 1 to 4 carbon atoms inclusive) alkyl, lower alkoxy or lower alkylthio;
R.sup.2 is hydrogen, hydroxy or methoxy;
R.sup.3 and R.sup.4 are independently selected from hydrogen or lower alkyl;
X is the divalent group ##STR24##

### Claim 2 (depends on 1)

The compound of claim 1, N-[2-[2-(1-methyl-2-piperidinyl)ethyl]phenyl]-p-anisamidine or a pharmaceutically acceptable salt thereof.