# US 4,399,279 A · 4H-1,4-Benzothiazine derivatives and intermediates thereto

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- Number: US 4,399,279 A
- Document ID: US4399279A
- Status: Granted
- Kind: A
- Application number: 06/373,329
- Filed: 1982-04-30
- Granted: 1983-08-16
- Earliest claimed: 1981-03-09
- Assignees: G.D. Searle & Co.
- Inventors: Robert J. Chorvat; Bipinchandra N. Desai; Suzanne E. Radak
- Web page: https://patentgrep.com/patent/US4399279A

## CPC

- C07D 513/04: Ortho-condensed systems
- C07D 279/16: condensed with one six-membered ring
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

4H-1,4 benzothiazine derivatives having anorectic activity and their preparation including intermediate compounds are disclosed.

## Claims

### Claim 1

An intermediate compound of the formula ##STR23## wherein W represents CN, CONH.sub.2 or CON.dbd.CHNXY, wherein X represents a lower alkyl of 1 to 4 carbon atoms and Y represents a lower alkyl of 1 to 4 carbon atoms; and R" represents hydrogen, methoxy, trifluoromethyl or lower alkyl having 1 to 4 carbon atoms when R''' represents hydrogen, and when R" represents halogen, R''' represents hydrogen or halogen.

### Claim 2 (depends on 1)

A compound according to claim 1 wherein W is CN.

### Claim 3 (depends on 2)

A compound according to claim 2 wherein R''' is hydrogen.

### Claim 4 (depends on 2)

A compound according to claim 2 wherein R''' is halogen.

### Claim 5 (depends on 1)

A compound according to claim 1 wherein W is CONH.sub.2.

### Claim 6 (depends on 5)

A compound according to claim 5 wherein R''' is hydrogen.

### Claim 7 (depends on 5)

A compound according to claim 5 wherein R''' is halogen.

### Claim 8 (depends on 1)

A compound according to claim 1 wherein W is CON.dbd.CHNXY.

### Claim 9 (depends on 8)

A compound according to claim 8 wherein X is CH.sub.3 and Y is CH.sub.3.

### Claim 10 (depends on 8)

A compound according to claim 8 wherein R''' is hydrogen.

### Claim 11 (depends on 8)

A compound according to claim 8 wherein R''' is halogen.