# US 4,398,045 A · Polyethylene glycol derivatives, their use and cosmetic and pharmaceutical compositions containing them

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- Number: US 4,398,045 A
- Document ID: US4398045A
- Status: Granted
- Kind: A
- Application number: 06/309,811
- Filed: 1981-10-08
- Granted: 1983-08-09
- Earliest claimed: 1980-10-10
- Assignees: L'oreal
- Inventors: Henri Sebag
- Web page: https://patentgrep.com/patent/US4398045A

## CPC

- A61K 8/86: Polyethers
- A61K 9/0014: {Skin, i.e. galenical aspects of topical compositions (non-active ingredients are additionally classified in A61K47/00; A61K9/0009, A61K9/0021, A61K9/7015, A61K9/7023 take precedence; cosmetic preparations A61K8/00, A61Q; preparations for wound dressings or bandages A61L26/00)}
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61P 43/00: Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A61Q 5/02: Preparations for cleaning the hair
- A61Q 19/10: Washing or bathing preparations
- C08G 65/06: Cyclic ethers having no atoms other than carbon and hydrogen outside the ring
- C08G 65/2609: {containing aliphatic hydroxyl groups}
- Y10S 424/05: Stick
- Y10S 516/01: Wetting, emulsifying, dispersing, or stabilizing agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61Q: SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- C08G: MACROMOLECULAR COMPOUNDS OBTAINED OTHERWISE THAN BY REACTIONS ONLY INVOLVING UNSATURATED CARBON-TO-CARBON BONDS
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The invention relates to new polyethylene glycol derivatives. These compounds correspond to the general formula: ##STR1## in which R denotes an alkyl and/or alkoxymethyl and/or alkenyloxymethyl radical or a mixture of these radicals, n denotes an average number of units from 20 to 500 and preferably from 30 to 200, and x and y denote average numbers of units from 0 to 8, it being possible for (x+y) to vary from 1 to 8. They can be used in cosmetic or pharmaceutical compositions, in particular as thickeners.

## Claims

### Claim 1

A product having the formula ##STR12## wherein each R represents, independently, alkyl having 8-18 carbon atoms, alkoxymethyl wherein the alkoxy moiety has 8-20 carbon atoms or alkenyloxy methyl wherein the alkenyl moiety has 8-20 carbon atoms, or a mixture thereof, n represents an average number from 20 to 500 and x and y independently represent an average number from 0 to 8 such that the sum (x+y) is from 1 to 8.

### Claim 2 (depends on 1)

A product according to claim 1 in which x and y denote an average number of units from 1 to 8 such that (x+y) is from 2 to 8.

### Claim 3 (depends on 1)

A product according to claim 1 in which n denotes an average number from 30 to 200.

### Claim 4 (depends on 1)

A product according to claim 1 in which the proportion by weight of the oxyethyleneated part represents 70 to 95% of the total product.

### Claim 5

A product having the formula ##STR13## wherein each R represents independently alkyl having 8 to 18 carbon atoms or a mixture thereof, n represents an average number from 20 to 500 and x and y independently represent an average number from 0 to 8 such that the sum (x+y) is from 1 to 8.

### Claim 6 (depends on 5)

The product of claim 5 wherein R is C.sub.14 H.sub.29, n is 68 and x+y is 3.

### Claim 7 (depends on 5)

The product of claim 5 wherein R, n and the sum (x+y) are selected from the following combinations:
(a) R is C.sub.14 H.sub.29, n is 45 and x+y is 3,
(b) R is C.sub.14 H.sub.29, n is 68 and x+y is 3,
(c) R is C.sub.10 H.sub.21, n is 68 and x+y is 4,
(d) R is C.sub.10 H.sub.21, n is 68 and x+y is 6,
(e) R is C.sub.14 H.sub.29, n is 90 and x+y is 3,
(f) R is C.sub.14 H.sub.29, n is 90 and x+y is 4,
(g) R is C.sub.10 H.sub.21, n is 136 and x+y is 4,
(h) R is C.sub.10 H.sub.21, n is 136 and x+y is 6,
(i) R is C.sub.16 H.sub.33, n is 136 and x+y is 3, and
(j) R is C.sub.14 H.sub.29, n is 454 and x+y is 8.