# US 4,398,026 A · 4-Carboxy-2-acetamido thiazolidine derivatives

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- Number: US 4,398,026 A
- Document ID: US4398026A
- Status: Granted
- Kind: A
- Application number: 06/383,526
- Filed: 1982-06-01
- Granted: 1983-08-09
- Earliest claimed: 1981-06-04
- Assignees: Taisho Pharmaceutical Co., Ltd.
- Inventors: Seiichi Takano; Susumu Otomo; Takehiro Amano
- Web page: https://patentgrep.com/patent/US4398026A

## CPC

- C07D 277/06: with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- A61P 37/04: Immunostimulants
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A novel thiazolidine derivative having the following general formula ##STR1## wherein R.sup.1 and R.sup.2 are each lower alkyl having 1 to 3 carbon atoms, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocyclic ring selected from the group consisting of morpholino, piperazino, piperidino and pyrrolidino, or said heterocyclic ring substituted with 1 or 2 methyl groups, and the pharmaceutically acceptable salts thereof are useful immunomodulators.

## Claims

### Claim 1

A thiazolidine derivative having the following general formula ##STR12## wherein R.sup.1 and R.sup.2 are each lower alkyl having 1 to 3 carbon atoms, or R.sup.1 and R.sup.2 together with the nitrogen atom to which they are attached form a heterocyclic ring selected from the group consisting of morpholino, piperazino, piperidino and pyrrolidino, or said heterocyclic ring substituted with 1 or 2 methyl groups, and the pharmaceutically acceptable salts thereof.

### Claim 2

4-carboxy-2,5,5-trimethylthiazolidine-2-N,N-dimethylacetamide.

### Claim 3

4-carboxy-2,5,5-trimethylthiazolidine-2-acetopyrrolidide.

### Claim 4

4-carboxy-2,5,5-trimethylthiazolidine-2-acetomorpholide.

### Claim 5

4-carboxy-2,5,5-trimethylthiazolidine-2-aceto-N-methylpiperazide.

### Claim 6

4-carboxy-2,5,5-trimethylthiazolidine-2-aceto-3,5-dimethylpiperidide.

### Claim 7

4-carboxy-2,5,5-trimethylthiazolidine-2-acetopiperidide.

### Claim 8

4-carboxy-2,5,5-trimethylthiazolidine-2-N,N-diethylacetamide.