# US 4,398,023 A · .beta.-1,3-Glucanpolyol, process for preparation thereof, and utilization thereof

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- Number: US 4,398,023 A
- Document ID: US4398023A
- Status: Granted
- Kind: A
- Application number: 06/182,617
- Filed: 1980-08-29
- Granted: 1983-08-09
- Earliest claimed: 1979-08-29
- Assignees: Meito Sangyo Kabushiki Kaisha
- Inventors: Hideki Miyachi; Akira Misaki; Mariko Kakuta; Mineo Nakayama; Hideo Nagae
- Web page: https://patentgrep.com/patent/US4398023A

## CPC

- C12P 19/04: Polysaccharides, i.e. compounds containing more than five saccharide radicals attached to each other by glycosidic bonds
- A61K 36/062: Ascomycota
- A61P 35/00: Antineoplastic agents
- C07H 3/06: Oligosaccharides, i.e. having three to five saccharide radicals attached to each other by glycosidic linkages
- C08B 37/0024: {beta-D-Glucans; (beta-1,3)-D-Glucans, e.g. paramylon, coriolan, sclerotan, pachyman, callose, scleroglucan, schizophyllan, laminaran, lentinan or curdlan; (beta-1,6)-D-Glucans, e.g. pustulan; (beta-1,4)-D-Glucans; (beta-1,3)(beta-1,4)-D-Glucans, e.g. lichenan; Derivatives thereof}
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- C08B: POLYSACCHARIDES; DERIVATIVES THEREOF (polysaccharides containing less than six saccharide radicals attached to each other by glycosidic linkages C07H; fermentation or enzyme-using processes C12P19/00; sugar industry C13; production of cellulose D21)

## Abstract

.beta.-1,3-glucanpolyol derived from .beta.-1,3-glucan produced by a .beta.-1,3-glucan-producing strain of the genus Pestalotia, said glucanpolyol having an intrinsic viscosity [.eta.] of about 1 to about 10 and comprising a main chain having as repeating units .beta.-1,3-glucopyranose units of the following formula .fwdarw.3) .beta.-D-Glc (1.fwdarw. wherein Glc represents a glucopyranose residual moiety, and bonded thereto, either side chains of formula (B), or both side chains of formulas (A) and (B) below ##STR1## wherein n represents a number of from 0 to 1, and .fwdarw.3) .beta.-D-Glc (1.fwdarw. represents the above main chain, and R represents a group derived from .beta.-D-glucopyranose of the formula ##STR2## a process for production thereof, and its pharmaceutical use.

## Claims

### Claim 1

.beta.-1,3-glucanpolyol derived from .beta.-1,3-glucan produced by a .beta.-1,3-glucan-producing strain of the genus Pestalotia, said glucanpolyol having the following characteristics [I] and [II]:
[I] said glucanpolyol comprises a main chain having as repeating units .beta.-1,3-glucopyranose units of the following formula
.fwdarw.3).beta.-D-Glc (1.fwdarw.
wherein Glc represents a glucopyranose residual moiety, and bonded thereto, either side chains of formula (B), or both side chains of formulas (A) and (B) below ##STR7## wherein n represents a number of from 0 to 1, and .fwdarw.3) .beta.-D-Glc (1.fwdarw. represents the above main chain, ##STR8## wherein n and .fwdarw.3) .beta.-D-Glc (1.fwdarw. are the same as defined with respect to formula (A), and R represents a groups derived from .beta.-D-glucopyranose of the formula ##STR9## said glucanpolyol has an intrinsic viscosity of about 1 to about 10 and wherein, per 100 .beta.-1,3-glucopyranose units of the main chain, the number of said side chains of formula (B) is about 25 to about 70, and the number of said side chains of formula (A) is 0 to about 45.