# US 4,397,995 A · Polymeric anti-tumor agent and method of preparation

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- Number: US 4,397,995 A
- Document ID: US4397995A
- Status: Granted
- Kind: A
- Application number: 06/221,087
- Filed: 1980-12-29
- Granted: 1983-08-09
- Earliest claimed: 1980-12-29
- Assignees: Monsanto Company
- Inventors: Marvin L. Oftedahl; Howard M. Solomon; James A. Webster
- Web page: https://patentgrep.com/patent/US4397995A

## CPC

- A61K 31/785: Polymers containing nitrogen
- A61P 1/04: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
- A61P 35/00: Antineoplastic agents
- C08F 8/44: Preparation of metal salts or ammonium salts
- C08F 8/48: Isomerisation; Cyclisation
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C08F: MACROMOLECULAR COMPOUNDS OBTAINED BY REACTIONS ONLY INVOLVING CARBON-TO-CARBON UNSATURATED BONDS

## Abstract

An improved pharmaceutically active derivative of a copolymer of olefin monomer and .alpha.,.beta.-unsaturated polycarboxylic anhydride is prepared by reacting the copolymer with aqueous ammonia, spray drying the resulting aqueous solution of half-amide, half-ammonium salt and thermally imidating the resulting substantially dry, solid particulate product by simultaneous treatment with elevated temperature and removal of water until 5-40% of the derivative half-amide, half-ammonium salt groups are converted to imide groups.

## Claims

### Claim 1

The method of making an improved pharmaceutically active derivative of a copolymer of an olefin monomer having from 2 to about 4 carbon atoms and an .alpha.,.beta.-unsaturated polycarboxylic anhydride having from 4 to about 6 carbon atoms, said copolymer having a number average molecular weight of from about 300 to about 1500, comprising reaction said copolymer with aqueous ammonia in an amount sufficient to form an aqueous solution of a copolymer derivative having half-amide, half-ammonium salt groups, spray drying said aqueous solution to provide a substantially dry particulate solid form of said copolymer derivative, and then thermally imidating said substantially dry copolymer derivative by simultaneous treatment with elevated temperature and removal of water until from about 5% to about 40% by weight of said derivative groups are converted to imide groups.

### Claim 2 (depends on 1)

The method of claim 1 in which the aqueous solution of the half-amide, half-ammonium salt copolymer derivative is vacuum distilled to remove from about 1% to about 2% by volume of a distillate prior to said spray drying.

### Claim 3 (depends on 1)

The method of claim 1 in which a small but effective amount of a water soluble bisulfite salt is incorporated in the aqueous solution of the half-amide, half-ammonium salt copolymer derivative prior to spray drying to prevent peroxide formation during said spray drying.

### Claim 4 (depends on 1)

The method of claim 1 in which the copolymer is a copolymer of ethylene and maleic anhydride.

### Claim 5 (depends on 1)

The method of claim 1 in which the imide groups comprise from about 10% to about 25% by weight of said derivatized groups.

### Claim 6 (depends on 1)

The method of claim 1 in which the copolymer has an average molecular weight of about 850.

### Claim 7 (depends on 4)

The method of claim 4 in which the imide groups comprise about 18% by weight of said derivatized groups and in which the copolymer has an average molecular weight of about 850.