# US 4,397,858 A · Treatment of rheumatism and arteriosclerosis with n-halogenophenyl-benzisothiazoles

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- Number: US 4,397,858 A
- Document ID: US4397858A
- Status: Granted
- Kind: A
- Application number: 06/313,810
- Filed: 1981-10-22
- Granted: 1983-08-09
- Earliest claimed: 1980-10-31
- Assignees: A. Nattermann & Cie GmbH
- Inventors: Andre Welter; Hans-Heiner Lautenschlager; Eugen Etschenberg; Sigurd Leyck
- Web page: https://patentgrep.com/patent/US4397858A

## CPC

- C07D 275/04: condensed with carbocyclic rings or ring systems
- A61K 31/425: Thiazoles
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

The invention relates to the new use of certain benzisothiazoles corresponding to the following general formula: ##STR1## wherein R.sub.1 represents chlorine, fluorine or bromine, and R.sub.2 represents hydrogen, chlorine, fluorine or bromine, in the treatment of phlogistic and/or arteriosclerotic processes.

## Claims

### Claim 1

A method for the treatment and prophylaxis of arthritis, inflammation and/or arteriosclerosis and resulting illnesses in humans or animals, which comprises administering to an animal an effective amount of a benzisothiazole corresponding to the following general formula: ##STR3## wherein R.sub.1 represents a radical selected from the group consisting of chlorine, fluorine and bromine, and R.sub.2 represents a radical selected from the group consisting of hydrogen, chlorine, fluorine and bromine.

### Claim 2 (depends on 1)

A method according to claim 1, wherein the animal is a human being.

### Claim 3 (depends on 1)

A method according to claim 1, wherein the benzisothiazole is 2-(4-chlorophenyl)-1,2-benzisothiazol-3(2H)-one.