# US 4,397,852 A · [3,6-Pyridazinediylbis(thio)]bis-[2,2-dimethylalkanoic acids] and derivatives as anti-arteriosclerotic agents and method

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- Number: US 4,397,852 A
- Document ID: US4397852A
- Status: Granted
- Kind: A
- Application number: 06/332,058
- Filed: 1981-12-18
- Granted: 1983-08-09
- Earliest claimed: 1981-12-18
- Assignees: Warner-Lambert Company
- Inventors: Ila Sircar
- Web page: https://patentgrep.com/patent/US4397852A

## CPC

- C07D 237/18: Sulfur atoms
- A61P 3/06: Antihyperlipidemics
- A61P 9/10: for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

New substituted [3,6-pyridazinediylbis(thio)]bis-[2,2-dimethylalkanoic acids] and derivatives which are useful as anti-arteriosclerotic agents are disclosed. These compounds elevate the high density lipoprotein fraction of cholesterol, and also lower the low density lipoprotein fraction of cholesterol.

## Claims

### Claim 1

A compound having the structural formula ##STR7## wherein n is 3; X is hydrogen, phenyl, or alkyl of from 1 to 6 carbon atoms; R is hydrogen, alkyl of from 1 to 6 carbon atoms or a pharmaceutically acceptable cation; and the pharmaceutically acceptable acid addition salts thereof.

### Claim 2 (depends on 1)

The compounds defined in claim 1 wherein R is methyl, and the pharmaceutically acceptable acid addition salts thereof.

### Claim 3 (depends on 1)

The compounds defined in claim 1 wherein R is hydrogen, an the pharmaceutically acceptable acid and base addition acids thereof.

### Claim 4 (depends on 1)

The compound defined in claim 1 which is dimethyl 5,5'-[3,6-pyridazinediylbis(thio)]bis [2,2-dimethylpentanoate] and the pharmaceutically acceptable acid addition salts thereof.

### Claim 5 (depends on 1)

The compound defined in claim 1 which is dimethyl 5,5'-[(4-phenyl-3,6-pyridazinediyl)bis(thio)]-bis[2,2-dimethylpentanoate] and the pharmaceutically acceptable acid addition salts thereof.

### Claim 6 (depends on 1)

The compound defined in claim 1 which is dimethyl 5,5'-[(4-methyl-3,6-pyridazinediyl)bis(thio)]-bis[2,2-dimethylpentanoate] and the pharmaceutically acceptable acid addition salts thereof.

### Claim 7

Dimethyl 6,6'-(3,6-pyridazinediylbis(thio)bis(2,2-dimethyl hexanoate) and the pharmaceutically acceptable acid addition salts thereof.

### Claim 8 (depends on 1)

The compound defined in claim 1 which is 5,5'-[3,6-pyridazinediylbis(thio)]bis[2,2-dimethylpentanoic acid] and the pharmaceutically acceptable acid and base addition salts thereof.

### Claim 9 (depends on 1)

A composition useful for treating artereosclerosis in a mammal consisting essentially of a compound defined in claim 1 or mixtures thereof, in combination with a pharmaceutically acceptable carrier.

### Claim 10 (depends on 9)

A method for treating arteriosclerosis in a mammal in need of such treatment; which comprises administering an effective amount of the pharmaceutical composition defined in claim 9 to said mammal.