# US 4,397,780 A · Leucine.sup.22 -calcitonin

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- Number: US 4,397,780 A
- Document ID: US4397780A
- Status: Granted
- Kind: A
- Application number: 06/348,396
- Filed: 1982-02-12
- Granted: 1983-08-09
- Earliest claimed: 1982-02-12
- Assignees: Armour Pharmaceutical Company
- Inventors: Ronald C. Orlowski; Jay K. Seyler
- Web page: https://patentgrep.com/patent/US4397780A

## CPC

- C07K 14/585: Calcitonins
- A61K 38/00: Medicinal preparations containing peptides (peptides containing beta-lactam rings A61K31/00; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, A61K31/00; ergot alkaloids of the cyclic peptide type A61K31/48; containing macromolecular compounds having statistically distributed amino acid units A61K31/74; medicinal preparations containing antigens or antibodies A61K39/00; medicinal preparations characterised by the non-active ingredients, e.g. peptides as drug carriers, A61K47/00)
- Y10S 530/855: Proteins from animals other than mammals or birds
- Y10S 530/857: Fish; fish eggs; shell fish; crustacea
- C07K: PEPTIDES (peptides in foodstuffs A23; obtaining protein compositions for foodstuffs, working-up proteins for foodstuffs A23J; preparations for medicinal purposes A61K; peptides containing beta-lactam rings C07D; cyclic dipeptides not having in their molecule any other peptide link than those which form their ring, e.g. piperazine-2,5-diones, C07D; ergot alkaloids of the cyclic peptide type C07D519/02; macromolecular compounds having statistically distributed amino acid units in their molecules, i.e. when the preparation does not provide for a specific; but for a random sequence of the amino acid units, homopolyamides and block copolyamides derived from amino acids C08G69/00; macromolecular products derived from proteins C08H1/00; preparation of glue or gelatine C09H; single cell proteins, enzymes C12N; genetic engineering processes for obtaining peptides C12N15/00; compositions for measuring or testing processes involving enzymes C12Q; investigation or analysis of biological material G01N33/00)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

Two new peptides are disclosed which have biological activity of the same type as known calcitonins and which are substitution analogs of natural calcitonins. Also resin peptides are disclosed which may be converted to peptides having such biological activity; and processes for producing said resin peptides and said calcitonin peptides.

## Claims

### Claim 1

A peptide having the structure: ##STR26##

### Claim 2

A peptide having the structure: ##STR27##

### Claim 3

A peptide having the structure: ##STR28## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H and H when R.sub.1 is S-n-alkyl or Cys, wherein S-n-alkyl is selected from the group consisting of methylthio, ethylthio, n-propylthio, n-butylthio, and equivalents thereof.

### Claim 4

A peptide having the structure: ##STR29## where R.sub.1 is S-n-alkyl, Cys or H and R.sub.2 is S-n-alkyl or H, R.sub.1 being S-n-alkyl, Cys or H when R.sub.2 is H and R.sub.2 being S-n-alkyl or H when R.sub.1 is H and H when R.sub.1 is S-n-alkyl or Cys, wherein S-n-alkyl is selected from the group consisting of methylthio, ethylthio, n-propylthio, n-butylthio, and equivalents thereof.

### Claim 5

A Leu-22 calcitonin selected from the group consisting of Leu-22 salmon calcitonin and Leu-22 eel calcitonin.