# US 4,396,764 A · Cyanoguanidine derivatives

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- Number: US 4,396,764 A
- Document ID: US4396764A
- Status: Granted
- Kind: A
- Application number: 06/302,360
- Filed: 1981-09-15
- Granted: 1983-08-02
- Earliest claimed: 1979-02-16
- Assignees: Eisai Co., Ltd.
- Inventors: Satoru Tanaka; Katsutoshi Shimada; Kazunori Hashimoto; Kiichi Ema; Koichiro Ueda
- Web page: https://patentgrep.com/patent/US4396764A

## CPC

- C07D 213/40: Acylated substituent nitrogen atom
- C07C 279/28: having nitrogen atoms of guanidine groups bound to cyano groups, e.g. cyanoguanidines, dicyandiamides
- C07D 213/89: with hetero atoms directly attached to the ring nitrogen atom
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Novel cyanoguanidine derivatives, and acid addition salts thereof useful as medicines which have pharmacological actions such as anti-secretory effect, local anesthesia action and the like; and process for the preparation thereof.

## Claims

### Claim 1

A compound of the formula ##STR209## wherein B is 2-, 3- or 4-pyridyl, R represents a group of the formula: ##STR210## wherein R.sub.1 and R.sub.2 are the same or different, and each represent a lower alkyl group, or together form a nitrogen-containing heterocycle of 5-member ring or 6-member ring which ring may also contain oxygen as hetero atom, and n is an integer of 1-3, or R represents a group of the formula ##STR211## wherein R.sub.3 is a lower alkyl group, n is an integer of 1-3, and m is an integer of 4-5.

### Claim 2 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR212##

### Claim 3 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR213##

### Claim 4 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR214##

### Claim 5 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR215##

### Claim 6 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR216##

### Claim 7 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR217##

### Claim 8 (depends on 1)

A compound according to claim 1 wherein B is 3-pyridyl and R is ##STR218##

### Claim 9 (depends on 1)

A compound according to claim 1 wherein B is 3-pyridyl and R is ##STR219##

### Claim 10 (depends on 1)

A compound according to claim 1 wherein B is 4-pyridyl and R is ##STR220##

### Claim 11 (depends on 1)

A compound according to claim 1 wherein B is 4-pyridyl and R is ##STR221##

### Claim 12 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR222##

### Claim 13 (depends on 1)

A compound according to claim 1 wherein B is 2-pyridyl and R is ##STR223##