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US 4,396,627 AGranted
Secondary amines, their preparation and use in pharmaceutical compositions
AssigneeBeecham Group Limited
InventorsAnthony T. Ainsworth, David G. Smith
Life of this patent
Estimating the term…
Abstract
Compounds having the formula: ##STR1## where R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5, Y and X are as defined hereinbelow, are useful for the reduction of abnormally high blood glucose and lipid levels in the treatment of obesity or hyperglycaemia.
Claims15
A compound of formula (II):
- ##STR19## or a pharmaceutically acceptable salt thereof, in which R.sub.1 is hydrogen, fluorine, chlorine, bromine, hydroxy, hydroxymethyl, methyl, methoxy, amino, formamido, acetamido, methylsulphonylamido, nitro, benzyloxy, methylsulphonylmethyl, uredio, trifluoromethyl or p-methoxybenzylamino;
- R.sub.2 is hydrogen, fluorine, chlorine, bromine or hydroxyl;
- R.sub.3 is hydrogen, chlorine or bromine or hydroxyl, R.sub.4 is alkyl of 1 to 10 carbon atoms substituted by hydroxyl, lower alkoxyl, oxo, lower acyloxy, carboxymethyoxy or carbo(lower alkoxy)methoxy;
- R.sub.5 is hydrogen, chlorine, fluorine, methyl, methoxy hydroxyl, or carboxy or lower alkyl ester or amide of said carboxy;
- R.sub.6 is hydrogen, methyl, ethyl or propyl;
- R.sub.7 is hydrogen, methyl, ethyl or propyl;
- X is a bond;
- and Y is alkylene of up to 6 carbon atoms or a bond.
5 more elements
Dependencies are inferred from the claim text.