# US 4,396,611 A · Glycosylglucans and application in gastroenterology

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- Number: US 4,396,611 A
- Document ID: US4396611A
- Status: Granted
- Kind: A
- Application number: 06/288,377
- Filed: 1981-07-30
- Granted: 1983-08-02
- Earliest claimed: 1980-08-05
- Assignees: Laboratoires Debat
- Inventors: Amaury N. C. Duc
- Web page: https://patentgrep.com/patent/US4396611A

## CPC

- A61K 31/715: Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61P 1/00: Drugs for disorders of the alimentary tract or the digestive system
- A61P 1/10: Laxatives
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The present invention relates to a medicament selected from the group consisting of glycosylglucans corresponding to the general formula ##STR1## (where n is an integer) and the molecular weight of which is between about 130,000 and 1,200,000 and preferably between about 500,000 and about 600,000. This medicament is particularly useful in gastroenterology and in particular in the treatment of disorders of the colon; it is administered by the oral route in association with a physiologically acceptable excipient.

## Claims

### Claim 1

A method of treating intestinal transit disorders comprising orally administering an effective intestinal transit improving amount of a glycosylglucan corresponding to the formula: ##STR5## wherein n represents an integer greater than about 200.

### Claim 2 (depends on 1)

A method according to claim 1 wherein said glycosylglucan is administered in the form of a capsule.

### Claim 3 (depends on 1)

A method according to claim 1 wherein said glycosylglucan is administered in the form of a gel.

### Claim 4 (depends on 1)

A method according to claim 1 wherein said glycosylglucan has a mean molecular weight from about 130,000 to about 1,200,000.

### Claim 5 (depends on 1)

A method according to claim 1 wherein n represents an integer from about 200 to about 1850.

### Claim 6 (depends on 1)

A method according to claim 1 wherein the mean molecular weight of said glycosylglucan is from about 500,000 to about 600,000.

### Claim 7 (depends on 1)

A method according to claim 1 wherein n is about 800.

### Claim 8 (depends on 1)

A method according to claim 1 wherein the specific rotation of said glycosylglucan in an alkaline medium at 25.degree. C. under nitrogen and at a concentration of 0.72 g/l is .alpha..sub.D.sup.25.degree. C. =100.degree./ml/g.

### Claim 9 (depends on 1)

A method according to claim 1 wherein said glycosylglucan is in the form of an aqueous sol, and said sol is viscous when at rest and fluid when agitated.