# US 4,396,602 A · Blood glucose level lowering agents

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- Number: US 4,396,602 A
- Document ID: US4396602A
- Status: Granted
- Kind: A
- Application number: 06/304,467
- Filed: 1981-09-22
- Granted: 1983-08-02
- Earliest claimed: 1981-09-22
- Assignees: Asahi Kasei Kogyo Kabushiki Kaisha
- Inventors: Akira Endo
- Web page: https://patentgrep.com/patent/US4396602A

## CPC

- A61K 38/45: Transferases (2)
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method of lowering the blood glucose level in mammals and a blood glucose level-lowering agent are described. The method comprises administering an enzyme capable of synthesizing sparingly-digestible saccharides from easily-digestible saccharides. The blood glucose level-lowering agent comprises the enzyme capable of synthesizing sparingly-digestible saccharides from easily-digestible saccharides and a glucosidase-inhibiting agent.

## Claims

### Claim 1

A method of lowering the blood glucose level in mammals capable of consuming easily-digestible saccharides and which require lowering of blood glucose level, comprising orally administering thereto an effective amount of an enzyme capable of synthesizing sparingly-digestible saccharides from said easily-digestible saccharides.

### Claim 2 (depends on 1)

A method as in claim 1, wherein the enzyme is administered together with a glucosidase-inhibiting agent.

### Claim 3 (depends on 1, 2)

A method as in claim 1 or 2, wherein the enzyme synthesizes sparingly-digestible polysaccharides or oligosaccharides from easily-digestible monosaccharides, oligosaccharides, or polysaccharides.

### Claim 4 (depends on 1, 2)

A method as in claim 1 or 2, wherein the enzyme is at least one member selected from dextransucrase and cyclodextrin-synthesizing enzymes.

### Claim 5 (depends on 4)

A method as in claim 4, wherein the dextransucrase is produced by a bacterium selected from the genera Leuconostoc and Streptococcus, and the cyclodextrin-synthesizing enzyme is produced by a bacterium selected from the genera Bacillus and Klebsiella.

### Claim 6 (depends on 1, 2)

A method as in claim 1 or 2, wherein the enzyme is dextransucrase produced by a strain belonging to the genus Streptococcus.

### Claim 7 (depends on 1, 2)

A method as in claim 1 or 2, wherein the enzyme is a cyclodextrin-synthesizing enzyme produced by a strain belonging to the genus Bacillus.

### Claim 8 (depends on 1)

A method as in claim 1, wherein the enzyme is orally administered in an amount of 1 to 100 mg/day.

### Claim 9 (depends on 2)

A method as in claim 2, wherein the mixture of the enzyme and the glucosidase-inhibiting agent is orally administered in an amount of 1 to 100 mg/day.

### Claim 10

A blood glucose level-lowering agent comprising effective amounts of an enzyme capable of synthesizing sparingly-digestible saccharides from easily-digestible saccharides and a glucosidase-inhibiting agent.

### Claim 11 (depends on 10)

A blood glucose level-lowering agent as in claim 10, wherein the glucosidase-inhibiting agent inhibits the amylase, sucrase, and maltase actions.

### Claim 12 (depends on 10)

A blood glucose level-lowering agent as in claim 10, wherein the weight ratio of the enzyme to the glucosidase-inhibiting agent is from 1/20 to 20/1.