# US 4,396,598 A · Triiodoisophthalamide X-ray contrast agent

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- Number: US 4,396,598 A
- Document ID: US4396598A
- Status: Granted
- Kind: A
- Application number: 06/338,382
- Filed: 1982-01-11
- Granted: 1983-08-02
- Earliest claimed: 1982-01-11
- Assignees: Mallinckrodt Inc.
- Inventors: Youlin Lin
- Web page: https://patentgrep.com/patent/US4396598A

## CPC

- A61K 49/04: X-ray contrast preparations
- C07C 233/00: Carboxylic acid amides
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Novel X-ray contrast agents, i.e., N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiod oisophthalamide.

## Claims

### Claim 1

N,N'-Bis(2,3- dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiodoisophthalamid e.

### Claim 2

A radiological composition containing N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiod oisophthalamide in a sufficient amount to provide satisfactory X-ray visualization together with a pharmaceutically acceptable radiological vehicle.

### Claim 3

In a method for X-ray visualization wherein a radiological composition containing an X-ray contrast agent in a pharmaceutically acceptable radiological vehicle is injected in a sufficient amount to provide adequate visualization and thereafter X-ray visualization carried out, the improvement comprising or utilizing as the radiological composition a composition containing N,N'-bis(2,3-dihydroxypropyl)-5-N-(2-hydroxyethyl)glycolamido-2,4,6-triiod oisophthalamide in a sufficient amount to provide satisfactory X-ray visualization together with a pharmaceutically acceptable radiological vehicle.