# US 4,395,577 A · Preparation of 3-chloromethyl-4-alkyl-nitrobenzene by chloromethylation

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- Number: US 4,395,577 A
- Document ID: US4395577A
- Status: Granted
- Kind: A
- Application number: 06/313,855
- Filed: 1981-10-22
- Granted: 1983-07-26
- Earliest claimed: 1981-10-22
- Assignees: American Cyanamid Company
- Inventors: Donald R. Maulding
- Web page: https://patentgrep.com/patent/US4395577A

## CPC

- A01N 33/20: containing oxygen or sulfur attached to the carbon skeleton containing the nitro group
- C07C 201/12: by reactions not involving the formation of nitro groups
- A01N: PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF (preservation of food or foodstuff A23); BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES (preparations for medical, dental or toiletry purposes which kill or prevent the growth or proliferation of unwanted organisms A61K); PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

A method for the preparation of 3-chloromethyl derivatives of 4-alkylnitrobenzenes from the corresponding amidomethyl derivatives with phosphorus oxychloride or with phosphorous oxychloride and inert solvents. This process also relates to 3-chloromethyl-4-alkylnitrobenzenes which are useful intermediates for the preparation of certain substituted 2,6-dinitroaniline pre-emergence herbicides.

## Claims

### Claim 1

A process for the preparation of a compound of structural formula: ##STR11## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl, comprising reacting an amide of structural formula: ##STR12## wherein R.sub.1 is C.sub.1 -C.sub.4 alkyl, R.sub.5 is C.sub.1 -C.sub.4 alkyl, C.sub.2 -C.sub.4 alkenyl, or phenyl, with phosphorus oxychloride alone or with phosphorus oxychloride in the presence of a solvent methylene chloride, chloroform, ethylene dichloride, benzene, toluene, xylene, chlorobenzene, dimethylformamide or mixtures thereof, at elevated temperatures up to and including the boiling point of the solvent or solvent misture, for a period of time sufficient to essentially complete the reaction, and wherein the amide to phosphorus oxychloride molar ratio is in the range of from 1:1 to 1:4; with the condition that when one of the components of the solvent mixture is dimethylformamide, then it is present in the solvent mixture in amounts of one to three molar equivalents per mole of amide.

### Claim 2 (depends on 1)

A process according to claim 1, wherein R.sub.1 is alkyl C.sub.1 -C.sub.4 ; R.sub.5 is methyl; the solvent is selected from ethylene dichloride, toluene, xylene, chlorobenzene, dimethylformamide and mixtures thereof; the amide to phosphorus oxychloride ratio is in the range of 1:1.5 to 1:2.1, and when the solvent mixture contains dimethylformamide, it is present in the mixture in 1.5 to 2 molar equivalents per mole of amide.

### Claim 3 (depends on 2)

A process according to claim 2, wherein R.sub.1 and R.sub.5 are both methyl; the reaction is carried out in the presence of a dimethylformamide-xylene solvent mixture, and the amide to phosphorus oxychloride to dimethylformamide molar ratio is 1:2.1:2.