# US 4,395,558 A · 9-Epi-mitomycin B and D compounds

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- Number: US 4,395,558 A
- Document ID: US4395558A
- Status: Granted
- Kind: A
- Application number: 06/323,847
- Filed: 1981-11-23
- Granted: 1983-07-26
- Earliest claimed: 1979-08-24
- Assignees: Kyowa Hakko Kogyo Co., Ltd.
- Inventors: Masaji Kasai; Kunikatsu Shirahata; Motomichi Kono
- Web page: https://patentgrep.com/patent/US4395558A

## CPC

- C07D 487/14: Ortho-condensed systems
- A61P 31/04: Antibacterial agents
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Mitomycin compounds of the general formula (I): ##STR1## wherein X is selected from an alkoxy group having 1 to 4 carbon atoms and amino group; and Z is selected from --OH, --OCONH.sub.2 and --OCO.sub.2 C.sub.6 H.sub.5 groups. The compounds of this formula may be used as starting materials for the preparation of various mitomycin compounds. When X is as hereinbefore defined and Z is --OCONH.sub.2, the compounds exhibit antibacterial activity and are of potential interest as medicaments. Preferred examples of the compounds are 9-Epi-mitomycin B and 9-epi-mitomycin D. The compounds of the formula (I) may be obtained from known mitomycin B or mitomycin D.

## Claims

### Claim 1

9-epi mitomycin B.

### Claim 2 (depends on 1)

The compound of claim 1 in substantially pure form.

### Claim 3

9-epi mitomycin D.

### Claim 4 (depends on 3)

The compound of claim 3 in substantially pure form.