# US 4,395,553 A · Chemical compounds

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- Number: US 4,395,553 A
- Document ID: US4395553A
- Status: Granted
- Kind: A
- Application number: 06/346,455
- Filed: 1982-02-08
- Granted: 1983-07-26
- Earliest claimed: 1981-05-18
- Assignees: Bristol-Myers Company
- Inventors: Aldo A. Algieri; Ronnie R. Crenshaw
- Web page: https://patentgrep.com/patent/US4395553A

## CPC

- C07D 209/48: with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C07D 211/46: having a hydrogen atom as the second substituent in position 4
- C07D 211/70: with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
- C07D 213/38: having only hydrogen or hydrocarbon radicals attached to the substituent nitrogen atom
- C07D 213/61: Halogen atoms or nitro radicals
- C07D 213/64: attached in position 2 or 6
- C07D 295/096: with the ring nitrogen atoms and the oxygen or sulfur atoms separated by carbocyclic rings or by carbon chains interrupted by carbocyclic rings
- C07D 307/52: Radicals substituted by nitrogen atoms not forming part of a nitro radical
- C07D 333/20: by nitrogen atoms (nitro, nitroso radicals C07D333/12)
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

Certain 1-(substituted amino)-2-(amino or substituted amino)cyclobutene-3,4-diones are potent histamine H.sub.2 -antagonists useful in the treatment of peptic ulcers.

## Claims

### Claim 1

A compound of the formula ##STR43## wherein R.sup.12 is a conventional leaving group selected from halogen, phenoxy, substituted phenoxy and (lower)alkoxy.

### Claim 2

1-Methoxy-2-[3-(3-piperidinomethylphenoxy)pro pylamino]-cyclobutene-3,4-dione.