# US 4,395,423 A · Polycyclic cyanoketones

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- Number: US 4,395,423 A
- Document ID: US4395423A
- Status: Granted
- Kind: A
- Application number: 06/100,983
- Filed: 1979-12-06
- Granted: 1983-07-26
- Earliest claimed: 1978-10-10
- Assignees: Sterling Drug Inc.
- Inventors: Helmut C. Neumann
- Web page: https://patentgrep.com/patent/US4395423A

## CPC

- C07D 261/20: condensed with carbocyclic rings or ring systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

(18.beta. and 18.alpha.)-2.alpha.-Cyano-3,11-dioxo-olean-12-en-29-oic acids and lower-alkyl esters thereof, useful as ulcer preventing and ulcer healing agents, are prepared from 18.beta.- or 18.alpha.-glycyrrhetinic acid, the final step being alkaline cleavage of 18.beta.- or 18.alpha.-11-oxo-olean-2,12-dieno[2,3-d]isoxazol-29-oic acid or an ester thereof.

## Claims

### Claim 1

A composition for the prevention and/or healing of gastric or intestinal ulcers in a mammal which comprises a therapeutically effective amount of a compound having the formula ##STR5## wherein R is hydrogen or lower-alkyl of one to three carbon atoms; a 3-lower-alkanoyl enol ester thereof wherein lower-alkanoyl has from two to four carbon atoms; or an alkali metal salt thereof incorporated in a pharmaceutical carrier suitable for oral administration.

### Claim 2 (depends on 1)

A method for the prevention and/or healing of gastric or intestinal ulcers in a mammal which comprises administering orally to said mammal a therapeutically effective amount of a composition according to claim 1.