# US 4,395,422 A · Spray dried vitamin E powder

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 4,395,422 A
- Document ID: US4395422A
- Status: Granted
- Kind: A
- Application number: 06/251,076
- Filed: 1981-04-06
- Granted: 1983-07-26
- Earliest claimed: 1981-04-06
- Assignees: BASF Wyandotte Corporation
- Inventors: Douglass N. Schmidt; Frank Fischetti, Jr.
- Web page: https://patentgrep.com/patent/US4395422A

## CPC

- A61K 47/42: Proteins; Polypeptides; Degradation products thereof; Derivatives thereof, e.g. albumin, gelatin or zein (oligopeptides having up to five amino acids {A61K47/183}; polyamino acids A61K47/34)
- A61K 9/2063: {Proteins, e.g. gelatin}
- A61P 3/02: Nutrients, e.g. vitamins, minerals
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

Spray dried vitamin E powders comprising 50 to 56 percent by weight vitamin E, 1 to 25 percent by weight hydrolyzed gelatin and 20 to 30 percent by weight caseinate. The resulting powders can be directly compressed into tablets of improved hardness and friability.

## Claims

### Claim 1

A vitamin E powder suitable for the preparation of direct compression vitamin tablets comprising 20 to 60 percent by weight Vitamin E, 0.5 to 2.0 percent by weight silicon dioxide having a particle size of 1 millimicron to 1 micron, 1 to 25 percent by weight hydrolyzed gelatin, and about 20 to 30 percent by weight caseinate, with the proviso that the weight ratio of caseinate to gelatin be greater than 1:1 all weight based on the total weight of powder.

### Claim 2

A vitamin E powder suitable for the preparation of direct compression vitamin tablets consisting essentially of 50 percent by weight to 56 percent by weight of vitamin E, 0.5 percent by weight to 2.0 percent by weight of silicon dioxide having a particle size of 1 millimicron to 1 micron, 1 percent by weight to 25 percent by weight of a hydrolyzed gelatin, about 20 percent by weight to about 30 percent by weight of a caseinate and the remainder to 100 percent by weight of a monoglyceride and/or a tabletting excipient, with the proviso that the weight ratio of caseinate to gelatin be greater than 1:1, all weights based on the total weight of powder.

### Claim 3 (depends on 2)

The powder of claim 2 wherein the vitamin E is vitamin E acetate.

### Claim 4 (depends on 2)

The powder of claim 2 wherein the tabletting excipient is lactose.

### Claim 5 (depends on 2)

The powder of claim 2 containing from 1.0 to 1.5 percent by weight monoglyceride.

### Claim 6

A vitamin E acetate powder suitable for the preparation of direct compression vitamin tablets comprising 50 percent by weight to 56 percent by weight vitamin E acetate, 1.0 percent by weight to 2.0 percent by weight silicon dioxide having a particle size of 1 millimicron to 1 micron, 1.0 percent by weight to 1.5 percent by weight distilled monoglyceride, 0 percent by weight to 22 percent by weight lactose, 10 percent by weight to 22 percent by weight hydrolyzed gelatin, and 20 percent by weight to 27 percent by weight caseinate, with the proviso that the weight ratio of caseinate to gelatin be greater than 1:1, all weights based on the total weight of powder.

### Claim 7 (depends on 6)

The powder of claim 6 containing 9 to 15 percent by weight lactose.

### Claim 8

A process for the preparation of spray dried vitamin E powder comprising:
A. emulsifying to a particle size of less than about 2 microns and a viscosity up to 1000 cps, 45 to 60 percent by weight deionized water, 22 to 28 percent by weight vitamin E acetate, 8 to 14 percent by weight caseinate, 0.4 to 13 percent by weight hydrolyzed gelatin, 0 to 1 percent by weight monoglyceride, and 0 to 11 percent by weight lactose, with the proviso that the weight ratio of caseinate to gelatin be greater than 1:1 and
B. spray drying the emulsion in the presence of from 0.5 percent by weight to 2.0 percent by weight silicon dioxide having a particle size of 1 millimicron to 1 micron, to form a non-agglomerated powder.