# US 4,395,420 A · Method and composition for treating pruritis

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- Number: US 4,395,420 A
- Document ID: US4395420A
- Status: Granted
- Kind: A
- Application number: 06/328,955
- Filed: 1981-12-09
- Granted: 1983-07-26
- Earliest claimed: 1981-12-09
- Inventors: Joel E. Bernstein
- Web page: https://patentgrep.com/patent/US4395420A

## CPC

- A61K 31/00: Medicinal preparations containing organic active ingredients
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

A method of and composition for treating pruritis comprising topically applying a therapeutically effective amount of a tricyclic anti-depressant in a pharmaceutically acceptable carrier. The tricyclic is present in the range of from about 0.1% to about 10% by weight of the carrier and is applied in divided doses.

## Claims

### Claim 1

A method of treating pruritis in humans in need of such treatment comprising topically applying a therapeutically effective amount of doxepin or a physiologically acceptable acid addition salt thereof.

### Claim 2 (depends on 1)

The method of claim 1, wherein the doxepin or acid addition salt thereof is present in a pharmaceutically acceptable carrier at a concentration of not less than about 0.1% by weight of the carrier.

### Claim 3 (depends on 1)

The method of claim 1, wherein the doxepin or the acid addition salt thereof is present in a pharmaceutically acceptable carrier at a concentration in the range of from about 0.1% by weight to about 10% by weight of the carrier.

### Claim 4 (depends on 1)

The method of claim 1, wherein the doxepin or the acid addition salt thereof is present in a pharmaceutically acceptable carrier at a concentration in the range of from about 0.5% by weight to about 5% by weight of the carrier.

### Claim 5 (depends on 1)

The method of claim 1, wherein the acid addition salt is selected from the class consisting of halides other than fluoride, acetate, valerate, and oleate.

### Claim 6 (depends on 5)

The method of claim 5, wherein the acid addition salt is doxepin hydrochloride and is present in the range of from 0.5% by weight to about 10% by weight of the carrier.

### Claim 7 (depends on 1)

The method of claim 1, wherein the carrier is an ointment or cream.

### Claim 8 (depends on 1)

The method of claim 1, wherein the carrier is an aqueous-alcohol solution.

### Claim 9

A composition for treating pruritis comprising a carrier pharmaceutically acceptable for topical application to the skin containing a therapeutic amount of doxepin or a physiologically acceptable acid addition salt thereof.

### Claim 10 (depends on 9)

The composition of claim 9, wherein the doxepin or acid addition salt thereof is present in the carrier at a concentration of not less than about 0.1% by weight of the carrier.

### Claim 11 (depends on 9)

The composition of claim 9, wherein the doxepin or acid addition salt thereof is present in the carrier at a concentration in the range of between about 0.1% by weight and about 10% by weight of the carrier.

### Claim 12 (depends on 9)

The composition of claim 9, wherein the doxepin or acid addition salt thereof is present in a pharmaceutically acceptable carrier at a concentration in the range of from about 0.5% by weight to about 5% by weight of the carrier.

### Claim 13 (depends on 9)

The composiition of claim 9, wherein the acid addition salt is selected from the class consisting of halides other than fluoride, acetate, valerate, and oleate.

### Claim 14 (depends on 13)

The composition of claim 13, wherein the acid addition salt is doxepin hydrochloride and is present in the range of from 0.5% by weight to about 10% by weight of the carrier.

### Claim 15 (depends on 9)

The composition of claim 9, wherein the carrier is an ointment or cream.

### Claim 16 (depends on 9)

The composition of claim 9, wherein the carrier is an aqueous-alcohol solution.