# US 4,395,405 A · Alkyl-ketohexopyranoside derivatives and method of use

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- Number: US 4,395,405 A
- Document ID: US4395405A
- Status: Granted
- Kind: A
- Application number: 06/150,129
- Filed: 1980-05-15
- Granted: 1983-07-26
- Earliest claimed: 1979-05-23
- Assignees: Hisamitsu Pharmaceutical Co., Inc.
- Inventors: Kanji Noda; Akira Nakagawa; Yasushi Haraguchi; Koichiro Ueda; Munehiko Hirano; Itsuo Nishioka; Akira Yagi; Akihide Koda; Hiroyuki Ide
- Web page: https://patentgrep.com/patent/US4395405A

## CPC

- C07H 15/04: attached to an oxygen atom of the saccharide radical
- A61P 35/00: Antineoplastic agents
- A61P 37/08: Antiallergic agents (antiasthmatic agents A61P11/06; ophthalmic antiallergics A61P27/14)
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

An alkyl-ketohexopyranoside derivative having pharmacological actions such as antiallergic actions, represented by the following general formula ##STR1## wherein R is an alkyl group having at least 3 carbon atoms, the derivatives excluding the D-fructose derivative wherein R is n-propyl group.

## Claims

### Claim 1

An antiallergic composition comprising an effective amount of an ingredient, which is a compound represented by the following general formula ##STR15## wherein R is an alkyl group having 3-6 carbon atoms, the compounds excluding the D-fructose derivatives of the .alpha.-type and D-fructose derivatives wherein R is n-propyl group, together with an inert carrier therefor.

### Claim 2 (depends on 1)

A composition according to claim 1, wherein R is n-propyl, isopropyl, n-butyl, isobutyl, n-pentyl, isopentyl, n-hexyl or isohexyl group in the general formula (I).

### Claim 3

The method of selectively treating the production of antibody immune globulins causing allergic diseases without inhibiting the production of immune globulins governing immune reaction by administering an antiallergic effective amount of a compound represented by the following general formula ##STR16## wherein R is an alkyl group having 3-6 carbon atoms, the compounds excluding the D-fructose derivative wherein R is n-propyl group.

### Claim 4

An alkyl-ketohexopyranoside derivative represented by the following general formula ##STR17## wherein R is an alkyl group having 3-6 carbon atoms, the alkyl-ketohexopyranoside derivative excluding the D-fructose derivatives of the .alpha.-type and D-fructose derivatives wherein R is an n-propyl group.

### Claim 5 (depends on 4)

An alkyl-ketohexopyranoside derivative according to claim 4, wherein R is n-propyl, isopropyl, n-butyl, isobutyl, n-pentyl, isopentyl, n-hexyl or isohexyl group in the general formula (I).