# US 4,395,398 A · Dental hemostatic composition

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- Number: US 4,395,398 A
- Document ID: US4395398A
- Status: Granted
- Kind: A
- Application number: 06/249,726
- Filed: 1981-03-31
- Granted: 1983-07-26
- Earliest claimed: 1980-04-02
- Assignees: Bee Brand Medico Dental Co., Ltd.
- Inventors: Hiroji Yamamoto
- Web page: https://patentgrep.com/patent/US4395398A

## CPC

- A61K 33/06: Aluminium, calcium or magnesium; Compounds thereof {, e.g. clay}
- A61K 31/70: Carbohydrates; Sugars; Derivatives thereof (sorbitol A61K31/047)
- A61K 33/26: Iron; Compounds thereof
- A61K 33/30: Zinc; Compounds thereof
- A61P 1/02: Stomatological preparations, e.g. drugs for caries, aphtae, periodontitis
- A61P 7/04: Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A liquid hemostatic composition for local application to small hemorrhage in the dental field which comprises one or more astringents selected from the group consisting of aluminum chloride, tannic acid, ferric chloride, zinc chloride and potassium aluminum sulfate; one or more surfactants selected from the group consisting of cetyl pyridinium chloride, benzalkonium chloride, benzethonium chloride, chlorhexidine, chlorhexidine gluconate, lauryl sulfate, a polyoxyethylene sorbitan fatty acid ester, a polyoxyethylene fatty acid ester, a polyoxyethylene higher alcohol ether, a polyoxyethylene alkyl aryl ether, a polyoxyethylene lanolin derivative, a polyoxyethylene lanolin alcohol derivative, a polyoxyethylene castor oil derivative, a polyoxypropylene-polyoxyethylene alkyl ether and a polyoxyethylene alkylphenol-formaldehyde condensate; and a carrier or diluent selected from the group consisting of water and a mixture of water and one or more pharmaceutically acceptable water-soluble organic solvents.

## Claims

### Claim 1

A liquid dental hemostatic composition consisting essentially of astringent, surfactant and carrier or diluent,
said astringent being a member selected from the group consisting of aluminum chloride, tannic acid, ferric chloride, zinc chloride and potassium aluminum sulfate and the amount of aluminum chloride being from 5 to 30 w/v%, the amount of tannic acid being 10 to 35 w/v%, the amount of ferric chloride being 5 to 25 w/v%, the amount of zinc chloride being 10 to 45 w/v% and the amount of potassium aluminum sulfate being 1 to 10 w/v%,
said surfactant being a member selected from the group consisting of cetyl pyridinium chloride, benzalkonium chloride, benzethonium chloride, sodium lauryl sulfate and a polyoxyethylene sorbitan fatty acid ester and the amount thereof being 0.01 to 2.0 w/v%, and
said carrier or diluent being a member selected from the group consisting of water and a mixture of water with ethanol, propylene glycol, glycerin or a polyoxyethylene glycol having polymerization degree of 200 to 400,
all percentages being based on the total composition.

### Claim 2 (depends on 1)

A composition according to claim 1 wherein the astringent is aluminum chloride.

### Claim 3 (depends on 1)

A composition according to claim 1 wherein the astringent is tannic acid.

### Claim 4 (depends on 1)

A composition according to claim 1 wherein the astringent is ferric chloride.

### Claim 5 (depends on 1)

A composition according to claim 1 wherein the astringent is zinc chloride.

### Claim 6 (depends on 1)

A composition according to claim 1 wherein the astringent is potassium aluminum sulfate.

### Claim 7

A method of improving hemostatic properties of an astringent-containing liquid dental composition, wherein the astringent comprises a member selected from the group consisting of aluminum chloride, tannic acid, ferric chloride, zinc chloride and potassium aluminum sulfate, which comprises incorporating in the composition from 0.01 to 2.0 w/v%, based on the total amount of said composition, of a surfactant selected from the group consisting of cetyl pyridinium chloride, benzalkonium chloride, benzethonium chloride, sodium lauryl sulfate and a polyoxyethylene sorbitan fatty acid ester.

### Claim 8 (depends on 1, 2, 3, 4, 5, 6)

A method of hemostasis of a small hemorrhage in the mouth which comprises locally applying, on a bleeding part of gums or mucosa in the mouth, an effective amount of a composition according to one of claims 2 to 6 and 1.