# US 4,395,393 A · Artificial blood emulsifiers

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 4,395,393 A
- Document ID: US4395393A
- Status: Granted
- Kind: A
- Application number: 06/291,264
- Filed: 1981-08-10
- Granted: 1983-07-26
- Earliest claimed: 1981-08-10
- Assignees: BASF Wyandotte Corporation
- Inventors: Irving R. Schmolka
- Web page: https://patentgrep.com/patent/US4395393A

## CPC

- A61K 9/0026: {Blood substitute; Oxygen transporting formulations; Plasma extender}
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

An artificial blood composition comprises a perfluoro chemical, physiological saline and a polyoxybutylene-polyoxyethylene block copolymer. The block copolymer provides stable emulsions.

## Claims

### Claim 1

An artificial blood comprising from 10 to 40 percent by weight of a perfluoro chemical, from 40 to 80 percent by weight physiological saline and from 2 to 8 percent by weight of a polyoxybutylene-polyoxyethylene block copolymer emulsifier, said emulsifier being a cogeneric mixture of conjugated polyoxybutylene-polyoxyethylene compounds containing in their structure oxybutylene groups, oxyethylene groups and an organic radical derived from a water-soluble organic compound containing a plurality of reactive hydrogen atoms and 2 to 12 carbon atoms; the compounds being characterized in that all of the oxybutylene groups are present in polyoxybutylene chains that are attached to the organic radical at the site of a reactive hydrogen atom thereby constituting a polyoxybutylene polymer; the oxyethylene groups being attached to the polyoxybutylene polymer in polyoxyethylene chains; the average molecular weight of the polyoxybutylene polymers in the mixture being between about 1200 and 3000, as determined by hydroxyl number, and the oxyethylene groups present constituting 60 to 85 percent by weight of the mixture.

### Claim 2 (depends on 1)

The artificial blood of claim 1 wherein the perfluoro chemical is selected from the group consisting of perfluorodecalin, perfluoromethyldecalin, perfluorotributylamine, and perfluoro 2,2,4,4 tetramethyl pentane.

### Claim 3 (depends on 2)

The artificial blood of claim 2 wherein the polyoxybutylene polymer has a molecular weight of about 1200.

### Claim 4 (depends on 2)

The artificial blood of claim 2 wherein the polyoxybutylene polymer has a molecular weight of about 1800.

### Claim 5 (depends on 1)

The artificial blood of claim 1 wherein the perfluoro chemical is perfluorodecalin and the polyoxybutylene polymer has a molcular weight of about 1200 and the oxyethylene content is about 80 percent by weight of the mixture.

### Claim 6 (depends on 1)

The artificial blood of claim 1 wherein the perfluoro chemical is perfluorodecalin and the emulsifier polyoxybutylene polymer has a molecular weight of about 1800 and the oxyethylene content is about 80 percent by weight of the mixture.