# US 4,395,392 A · Method for treating kidney stones

> Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt

- Number: US 4,395,392 A
- Document ID: US4395392A
- Status: Granted
- Kind: A
- Application number: 06/278,014
- Filed: 1981-06-29
- Granted: 1983-07-26
- Earliest claimed: 1980-06-24
- Assignees: Adria Laboratories, Inc.
- Inventors: Richard L. Wolgemuth
- Web page: https://patentgrep.com/patent/US4395392A

## CPC

- A61K 31/795: Polymers containing sulfur
- A61K 31/74: Synthetic polymeric materials
- A61P 13/02: of urine or of the urinary tract, e.g. urine acidifiers
- A61P 15/00: Drugs for genital or sexual disorders (for disorders of sex hormones A61P5/24); Contraceptives
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

A method for decreasing urinary calcium content which comprises orally administering to a person whose urine contains insoluble calcium containing precipitates or has a propensity for forming calcium containing precipitates, an effective amount of an agent selected from water-soluble vinylbenzenesulfonic acid polymers and the nontoxic pharmaceutically acceptable salts thereof.

## Claims

### Claim 1

A treatment for decreasing urinary calcium content which comprises orally administering to a host in need of such treatment, a therapeutically effective amount of an agent selected from water-soluble vinylbenzenesulfonic acid polymers having a viscosity average molecular weight in the range of from about 50,000 to about 500,000 and containing less than 5% by weight of polymers having a molecular weight of less than 20,000, wherein the polymers have from about 70 to over 90% molar monosulfonation and the nontoxic pharmaceutically acceptable salts thereof.

### Claim 2

A treatment for decreasing urinary calcium content which comprises orally administering to a hose in need of such treatment, a therapeutically effective amount of a vinylbenzenesulfonic acid homopolymer having a viscosity average molecular weight range of from about 50,000 to about 500,000 and containing less than 5% by weight of polymers having a molecular weight of less than 20,000, having repeating units of the formula ##STR3## wherein the polymer has from about 70 to over 90% molar monosulfonation and nontoxic pharmaceutically acceptable salts thereof.