# US 4,394,527 A · Method for the liquid phase oxidative fluorination of aromatic compounds

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- Number: US 4,394,527 A
- Document ID: US4394527A
- Status: Granted
- Kind: A
- Application number: 06/087,135
- Filed: 1979-10-22
- Granted: 1983-07-19
- Earliest claimed: 1979-10-22
- Assignees: American Cyanamid Company
- Inventors: Robert G. Fischer, Jr.; Arnold Zweig
- Web page: https://patentgrep.com/patent/US4394527A

## CPC

- C07C 17/12: in the ring of aromatic compounds
- C07B 39/00: Halogenation
- C07C 17/04: to unsaturated halogenated hydrocarbons
- C07C 17/21: with simultaneous increase of the number of halogen atoms
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07B: GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR (preparation of carboxylic acid esters by telomerisation C07C67/47; telomerisation C08F)

## Abstract

There is provided a process for effecting fluorination of benzene, p-difluorobenzene or p-dichlorobenzene by subjecting the same to the action of argentic fluoride (AgF.sub.2) in the liquid phase to obtain fluorobenzene from benzene or a fluorinated cyclohexadiene from halogenated benzene, respectively, in good yield and purity.

## Claims

### Claim 1

A process for monofluorinating a benzene nucleus which comprises: reacting at a temperature ranging from about 25.degree. C. to about 100.degree. C. in the liquid phase a benzene compound with argentic fluoride in the range of from about 0.1 mol to about 1 mol per mol of said benzene compound, said compound being dissolved in an inert solvent therefor present in amounts ranging from about 99% to 50% solvent and the remainder being said benzene compound for a time sufficient to convert said argentic fluoride to argentous fluoride, and recovering said fluorinated benzene compound in good yield and purity.

### Claim 2 (depends on 1)

The process according to claim 1 wherein the reaction is carried out under reflux temperatures.

### Claim 3 (depends on 1)

The process according to claim 1 wherein the reaction is carried out in hexane.

### Claim 4 (depends on 1)

The process according to claim 1 wherein the benzene compound is benzene.