# US 4,394,504 A · Cephalosporin derivatives

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- Number: US 4,394,504 A
- Document ID: US4394504A
- Status: Granted
- Kind: A
- Application number: 06/309,361
- Filed: 1981-10-07
- Granted: 1983-07-19
- Earliest claimed: 1981-10-07
- Assignees: American Home Products Corporation
- Inventors: Thomas J. Commons; John R. Potoski
- Web page: https://patentgrep.com/patent/US4394504A

## CPC

- C07D 261/14: Nitrogen atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

7-[2-(3-Amino-5-isoxazolyl)-2-alkyloxy-iminoacetamido]-ceph-3-em-4-carboxyl ic acid derivatives are antibacterial agents effective against gram-positive and gram-negative bacterium.

## Claims

### Claim 1

A compound of the formula: ##STR6## in which: R.sup.1 is H, alkyl of 1 to 4 carbon atoms, alkenyl of 2 to 4 carbon atoms, alkynyl of 2 to 4 carbon atoms, arylalkyl of 7 to 10 carbon atoms, 2-carboxyprop-2-yl, carboxymethyl, alkanoyl of 2 to 4 carbon atoms or .alpha.-phenylalkanoyl of 8 to 10 carbon atoms;
R.sup.2 is H, hydroxy, alkanoyloxy of 2 to 6 carbon atoms, carbamoyloxy, ##STR7## where R.sup.4 is hydrogen or alkyl of 1 to 4 carbon atoms or ##STR8## where R.sup.5 is hydrogen or alkyl of 1 to 4 carbon atoms, vinyl, sulfonyloxymethyl or carboxymethyl;
or a pharmaceutically acceptable salt thereof.

### Claim 2 (depends on 1)

The compound of claim 1 which is 3-acetoxymethyl-7-[2-(3-amino-5-isoxazolyl)-2-syn-methoxyiminoacetamido]-c eph-3-em-4-carboxylic acid or a pharmaceutically acceptable salt thereof.

### Claim 3 (depends on 1)

The compound of claim 1 which is 3-acetoxymethyl-7-[2-(3-amino-5-isoxazolyl)-2-anti-methoxyiminoacetamido]- ceph-3-em-4-carboxylic acid or a pharmaceutically acceptable salt thereof.