# US 4,394,452 A · Synthetic stool

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- Number: US 4,394,452 A
- Document ID: US4394452A
- Status: Granted
- Kind: A
- Application number: 05/910,285
- Filed: 1978-05-30
- Granted: 1983-07-19
- Earliest claimed: 1977-05-31
- Assignees: Rohm Co., Ltd.
- Inventors: Roland Hartl; Dieter Helm
- Web page: https://patentgrep.com/patent/US4394452A

## CPC

- G01N 33/96: involving blood or serum control standard
- Y10T 436/105831: Protein or peptide standard or control [e.g., hemoglobin, etc.]
- Y10T 436/106664: Blood serum or blood plasma standard or control
- G01N: INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES (measuring or testing apparatus or processes other than immunoassay, involving enzymes or microorganisms C12M, C12Q)
- Y10T: TECHNICAL SUBJECTS COVERED BY FORMER US CLASSIFICATION

## Abstract

Synthetic stool, adaptable to use as a control standard in the diagnostic detection of substances contained in stools and for demonstration purposes, said stool comprising a matrix of a member selected from the group consisting of oxygen-containing organic polymers which are difficultly soluble in water and oxygen-containing inorganic solids difficultly soluble in water, a non-bleeding coloring agent adherent to said matrix and simulating the color of a stool, and a liquid selected from the group consisting of water and lubricants.

## Claims

### Claim 1

A synthetic human stool, spreadable on a substrate and adaptable to use as a control standard in the diagnostic detection of occult blood in the stool, said synthetic stool consisting essentially of a matrix of a member selected from the group consisting of oxygen-containing organic polymers which are difficultly soluble in water and oxygen-containing inorganic solids difficultly soluble in water, a non-bleeding coloring agent adherent to said matrix and simulating the color of a human stool, a liquid selected from the group consisting of water and lubricants, and a predetermined amount of hemolyzed human blood, said coloring agent on treatment with hydrogen peroxide showing no change in color or no change in color interfering with such a diagnostic detection of occult blood.

### Claim 2 (depends on 1)

The method of checking, standardizing, or comparison testing a diagnostic test strip for the detection of blood in the stool which comprises applying a test quantity of a synthetic stool as in claim 1 to said test strip, applying hydrogen peroxide to the test strip, and observing a detectable response.