# US 4,394,446 A · Process for the preparation of the antibiotic oxanosine

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- Number: US 4,394,446 A
- Document ID: US4394446A
- Status: Granted
- Kind: A
- Application number: 06/323,650
- Filed: 1981-11-20
- Granted: 1983-07-19
- Earliest claimed: 1980-11-22
- Assignees: Zaidan Hojin Biseibutsu Kagaku Kenkyu Kai
- Inventors: Hamao Umezawa; Nobuyoshi Shimada; Hiroshi Naganawa; Tomohisa Takita; Masa Hamada; Tomio Takeuchi
- Web page: https://patentgrep.com/patent/US4394446A

## CPC

- C12N 1/205: Bacterial isolates
- A61P 31/04: Antibacterial agents
- A61P 31/12: Antivirals
- A61P 35/00: Antineoplastic agents
- C07H 19/24: Heterocyclic radicals containing oxygen or sulfur as ring hetero atom
- C12P 19/28: N-glycosides
- C12R 2001/465: Streptomyces
- Y10S 435/886: Streptomyces
- C12N: MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA (microbiological testing media C12Q1/00)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- C07H: SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS (derivatives of aldonic or saccharic acids C07C, C07D; aldonic acids, saccharic acids C07C59/105, C07C59/285; cyanohydrins C07C255/16; glycals C07D; compounds of unknown constitution C07G; polysaccharides, derivatives thereof C08B; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; sugar industry C13)
- C12P: FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE {(brewing of beer C12C; producing vinegar C12J; producing specific peptides or proteins C07K; producing enzymes C12N9/00; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification C12N15/00; measuring or testing processes involving enzymes or microorganisms C12Q; measuring or testing processes involving nucleic acid amplification reactions C12Q1/6844; fermentation processes to form a food composition, A21 or A23; compounds in general, see the relevant compound class, e.g. C01, C07)}
- C12R: INDEXING SCHEME ASSOCIATED WITH SUBCLASSES C12C - C12Q, RELATING TO MICROORGANISMS
- Y10S: TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS

## Abstract

The novel antibiotic, oxanosine, having the structure ##STR1## inhibits the growth of Gram-negative bacteria and has antiviral and carcinostatic activity. It is produced by cultivation of an oxanosine-producing microorganism of the genus Streptomyces, preferably Streptomyces capreolus MG265-CF3, ATCC No. 31963.

## Claims

### Claim 1

A process for the preparation of the antibiotic oxanosine which comprises cultivating Streptomyces capreolus MG265-CF3, ATCC No. 31963 until a substantial amount of oxanosine is accumulated in the culture medium, and recovering the oxanosine from the culture medium.

### Claim 2 (depends on 1)

The process of claim 1 wherein the cultivation is carried out in an aqueous medium under submerged aerobic conditions.

### Claim 3

A biologically pure culture of Streptomyces capreolus MG265-CF3, ATCC No. 31963.