# US 4,394,319 A · Co-ordination compound of platinum

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- Number: US 4,394,319 A
- Document ID: US4394319A
- Status: Granted
- Kind: A
- Application number: 06/296,478
- Filed: 1981-08-26
- Granted: 1983-07-19
- Earliest claimed: 1980-09-03
- Assignees: Johnson Matthey Public Limited Company
- Inventors: Paul C. Hydes; Derek R. Hepburn
- Web page: https://patentgrep.com/patent/US4394319A

## CPC

- C07F 15/0093: {without a metal-carbon linkage}
- C07F: ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM (metal-containing porphyrins C07D487/22)

## Abstract

The compound ##STR1## useful for the chemotherapeutic treatment of cancer or malignant neoplasms is provided in substantially pure form by a method of preparation involving a novel intermediate adduct with dimethylacetamide.

## Claims

### Claim 1

A process for the preparation of a co-ordination compound of platinum in substantially pure form and having the structure ##STR6## comprising reacting cis-dichloro-di(isopropylamine)platinum(II) with hydrogen peroxide, isolating the product, dissolving the said product in N,N-dimethylacetamide, isolating the resulting product which comprises a 1:1 adduct of the said compound with N,N-dimethylacetamide and thereafter removing the said N,N-dimethylacetamide under vacuum at a temperature less than 80.degree. C.

### Claim 2 (depends on 1)

A process according to claim 1 in which the N,N-dimethylacetamide is removed under vacuum at a temperature less than 50.degree. C.

### Claim 3

A composition of matter comprising a 1:1 adduct of cis-dichloro-trans-dihydroxy-bis(isopropylamine)platinum(IV) with dimethylacetamide.