# US 4,394,311 A · Production of 2-benzazepines

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- Number: US 4,394,311 A
- Document ID: US4394311A
- Status: Granted
- Kind: A
- Application number: 06/324,208
- Filed: 1981-11-23
- Granted: 1983-07-19
- Earliest claimed: 1979-02-07
- Assignees: Hoffmann-La Roche Inc.
- Inventors: Eugene J. Trybulski
- Web page: https://patentgrep.com/patent/US4394311A

## CPC

- C07D 209/48: with oxygen atoms in positions 1 and 3, e.g. phthalimide
- C07C 45/63: by introduction of halogen; by substitution of halogen atoms by other halogen atoms
- C07C 45/71: being hydroxy groups
- C07D 223/16: Benzazepines; Hydrogenated benzazepines
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- C07C: ACYCLIC OR CARBOCYCLIC COMPOUNDS

## Abstract

Compounds of the formula ##STR1## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, are disclosed. The compounds are useful as intermediates in the production of 2-benzazepines, compounds of pharmacological activity. Also disclosed are other intermediates and processes for their production.

## Claims

### Claim 1

A process to produce a compound of the formula ##STR6## wherein X and Y are selected from the group consisting of hydrogen, halogen and trifluoromethyl, which consists essentially of the reaction of a compound of the formula ##STR7## wherein X and Y are as above, with a mixture of a catalytic amount of mercuric sulfate and an excess of a C.sub.1 to C.sub.4 carboxylic acid in an inert solvent at from about -10.degree. C. to room temperature.