# US 4,393,863 A · Extravascular circulation of oxygenated synthetic nutrients to treat tissue hypoxic and ischemic disorders > Agents: this data is available as JSON from the patentgrep API and MCP server — see https://patentgrep.com/llms.txt - Number: US 4,393,863 A - Document ID: US4393863A - Status: Granted - Kind: A - Application number: 06/275,116 - Filed: 1981-06-18 - Granted: 1983-07-19 - Earliest claimed: 1980-08-14 - Assignees: Thomas Jefferson University - Inventors: Jewell L. Osterholm - Web page: https://patentgrep.com/patent/US4393863A ## CPC - A61K 9/0026: {Blood substitute; Oxygen transporting formulations; Plasma extender} - A61K 9/0029: {Parenteral nutrition; Parenteral nutrition compositions as drug carriers} - A61K 31/02: Halogenated hydrocarbons - A61M 3/02: Enemata; Irrigators - A61M 3/0216: {Pressure} - A61M 3/022: {Volume; Flow rate} - A61M 2025/028: {having a mainly rigid support structure} - A61M 2202/0476: Oxygenated solutions - A61M 2205/3653: by Joule effect, i.e. electric resistance - A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D) - A61M: DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY (introducing media into or onto the bodies of animals A61D7/00; means for inserting tampons A61F13/26; devices for administering food or medicines orally A61J; containers for collecting, storing or administering blood or medical fluids A61J1/05); DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY (surgery A61B; chemical aspects of surgical articles A61L); DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR {(Electrotherapy, e.g. producing anaesthesia by the use of alternating or intermittent currents A61N1/36021)} ## Abstract A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided. ## Claims ### Claim 1 A method of treating hypoxic-ischemic neurologic tissue, in mammals, comprising: (a) providing a physiologically acceptable synthetic oxygenatable fluid; (b) oxygenating said oxygenatable fluid to produce an oxygenated fluid; (c) injecting a substantially continuous stream of said oxygenated fluid into the cerebrospinal fluid pathway, at a first injection point; (d) substantially continuously withdrawing fluid from said cerebrospinal fluid pathway at a second point which is selected to create a circulation of said oxygenated fluid in the vicinity of said ischemic tissue; whereby ischemic neurologic tissue will be oxygenated and otherwise nourished by said fluid. ### Claim 2 (depends on 1) The method of claim 1 wherein said first point is within a cerebral ventricle. ### Claim 3 (depends on 2) The method of claim 2 wherein said first point is within the lateral ventricle. ### Claim 4 (depends on 1) The method of claim 1 wherein said second point is within a subarachnoid space. ### Claim 5 (depends on 1) The method of claim 1 wherein said second point is within a cerebral cistern. ### Claim 6 (depends on 5) The invention of claim 5 wherein said cerebral cistern is the cisterna magna. ### Claim 7 (depends on 4) The invention of claim 4 wherein said subarachnoid space is a spinal subarachnoid space. ### Claim 8 (depends on 7) The invention of claim 7 wherein said spinal subarachnoid space is a lumbar spinal subarachnoid space. ### Claim 9 A method of treating spinal cord injuries, comprising: (a) providing a physiologically acceptable synthetic oxygenatable fluid; (b) oxygenating said oxygenatable fluid to produce and oxygenated fluid; (c) injecting said fluid substantially continuously into the subarachnoid space at a first point; and (d) oxygenated said fluid from said subarachnoid space at a second point, said first and second points being selected to establish circulation of said oxygenatable fluid around the vicinity of spinal cord injury. ### Claim 10 (depends on 9) The invention of claim 9 wherein said fluid further comprises cellular nutrients. ### Claim 11 (depends on 9) The invention of claim 9 wherein said first point is within lumbar spinal subarachnoid space. ### Claim 12 (depends on 9) The invention of claim 9 wherein said second point is within the cisterna magna. ### Claim 13 (depends on 1) The invention of claim 1 wherein said first point is within a subarachnoid space. ### Claim 14 (depends on 1) The method of claim 1 wherein said fluid is injected at a rate of between 1 ml/minute and 200 ml/minute. ### Claim 15 (depends on 14) The method of claim 14 wherein said fluid is withdrawn at a rate which selected to maintain the hydraulic pressure of said fluid with the CSF pathway at between about 25 mm and 250 mm of water. ### Claim 16 (depends on 1) The method of claim 1 wherein said fluid is injected at a rate of between about 10 ml/min/100 gms of ischemic-hypoxic neurologic tissue to be treated and 30 ml/min/100 gms of said tissue to be treated. ### Claim 17 (depends on 16) The method of claim 16 wherein said injection rate is about 20 ml/min/100 gms of tissue to be treated. ### Claim 18 (depends on 1) The method of claim 1 wherein said fluid is injected at a hydraulic pressure which does not excede 250 mm of water.