# US 4,393,210 A · 1(2H)-Isoquinolone compounds and acid addition salts thereof

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- Number: US 4,393,210 A
- Document ID: US4393210A
- Status: Granted
- Kind: A
- Application number: 06/182,188
- Filed: 1980-08-28
- Granted: 1983-07-12
- Earliest claimed: 1980-08-28
- Assignees: Seiyaku Co., Ltd.; Taiho Pharmaceutical Co., Ltd.
- Inventors: Shigeo Senda; Eiichi Katho; Osamu Ohtani; Hidekazu Miyake; Khosuke Fujiwara
- Web page: https://patentgrep.com/patent/US4393210A

## CPC

- C07D 217/26: Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
- C07D 217/24: Oxygen atoms
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)

## Abstract

1(2H)-Isoquinolone compounds represented by the formula (1) ##STR1## wherein Y represents hydrogen, chlorine or a methoxy group, Z represents a straight chain or branched chain divalent saturated aliphatic hydrocarbon group having 2 to 4 carbon atoms, R.sub.1 represents a cyano group, a lower alkoxycarbonyl group, a carbamoyl group, an N-substituted carbamoyl group, a phenyl group or a substituted phenyl group, R.sub.2 represents hydrogen or a lower alkyl group, and R.sub.3 represents a lower alkyl group, or R.sub.2 and R.sub.3 can form, when taken together with the nitrogen atom to which they are attached, a heterocyclic group, and the acid addition salts thereof, useful as analgesic, gastric secretion inhibitory, anti-depression, anti-histamine, anti-cholinergic and anti-ulcer agents.

## Claims

### Claim 1

1(2H)-Isoquinolone compounds represented by the formula (I) ##STR14## wherein Y represents hydrogen, chlorine or a methoxy group, Z represents a straight chain or branched chain divalent saturated aliphatic hydrocarbon group having 2 to 4 carbon atoms, R.sub.1 represents a cyano group, a lower alkoxycarbonyl group, a carbamoyl group, N-alkylcarbamoyl having 1 to 4 carbon atoms in the alkyl moiety, N,N-dialkylcarbamoyl having 1 to 4 carbon atoms in each alkyl moiety, 4-methylpiperazinocarbonyl or morpholinocarbonyl, a phenyl group or halophenyl or alkoxyphenyl having 1 to 4 carbon atoms in the alkoxy moiety, R.sub.2 represents hydrogen or a lower alkyl group, R.sub.3 represents a lower alkyl group, or R.sub.2 and R.sub.3 can form, when taken together with nitrogen atom to which they are attached, pyrrolidino, piperidino, 4-methylpiperazino, 4-hydroxyethylpiperazino or morpholino, and the pharmaceutically acceptable acid addition salts thereof.

### Claim 2 (depends on 1)

2-(3-N,N-Dimethylaminopropyl)-4-phenyl-1(2H)-isoquinolone or the acid addition salt thereof according to claim 1.

### Claim 3 (depends on 1)

2-(2-N,N-Dimethylaminoethyl-4-phenyl-1(2H)-isoquinolone or the acid addition salt thereof according to claim 1.

### Claim 4 (depends on 1)

4-Cyano-2-(3-N,N-dimethylaminopropyl)-1(2H)-isoquinolone and the acid addition salt thereof according to claim 1.

### Claim 5 (depends on 1)

2-(2-N,N-Dimethylaminopropyl)-4-phenyl-1(2H)-isoquinolone and the acid addition salt thereof according to claim 1.