Quinone compounds and their use in suppressing the production of SRS-A in mammals

A compound of the formula:

• ##STR130## wherein R.sup.1 is methyl or methoxy, or the two R.sup.1 groups jointly represent --CH.dbd.CH--CH.dbd.CH--,
• X is --CH.dbd.CH-- or --C.tbd.C--,
• Y.sup.1 is hydrogen, carboxyl, cyano, C.sub.2-4 alkanoyloxy, benzoyloxy or --COZ in which Z is amino or mono- or di-C.sub.1-4 alkylamino,
• m is zero or an integer of 1 to 3,
• n is zero or an integer of 1 to 10,
• n' is an integer of 1 to 5,
• k is an integer of 1 to 3, and
• when k is 2 or 3, n' is optionally variable within the range of 1 to 5 in each occurrence of the --X--(CH.sub.2).sub.n' group,
• with the proviso that there are 8-15 carbon atoms in series between the quinone ring and Y.sup.1,
• or its hydroquinone form,
• or a pharmaceutically acceptable salt thereof.

A pharmaceutical composition suitable for suppressing the production of SRS-A in a mammal which comprises, as an active ingredient, an effective amount of a compound of the formula:

• ##STR131## wherein R.sup.1 is methyl or methoxy, or the two R.sup.1 groups jointly represent --CH.dbd.CH--CH.dbd.CH--,
• X is --CH.dbd.CH-- or --C.tbd.C--,
• Y.sup.1 is hydroxyl,
• m is zero or an integer of 1 to 3,
• n is zero or an integer of 1 to 10,
• n' is an integer of 1 to 5,
• k is an integer of 1 to 3, and
• when k is 2 or 3, n' is optionally variable within the range of 1 to 5 in each occurrence of the --X--(CH.sub.2).sub.n' group,
• or its hydroquinone form,
• or a pharmaceutically acceptable salt thereof,
• and a pharmaceutically acceptable carrier or excipient therefor.

A pharmaceutical composition suitable for suppressing the production of SRS-A in a mammal which comprises, as an active ingredient, an effective amount of a compound of the formula:

• ##STR132## wherein R.sup.1 is methyl or methoxy, or the two R.sup.1 groups jointly represent --CH.dbd.CH--CH.dbd.CH--,
• X is --CH.dbd.CH-- or --C.tbd.C--,
• Y.sup.1 is hydrogen, carboxyl, cyano, C.sub.2-4 alkanoyloxy, benzoyloxy or --COZ in which Z is amino or mono- or di-C.sub.1-4 alkylamino,
• m is zero or an integer of 1 to 3,
• n is zero or an integer of 1 to 10,
• n' is an integer of 1 to 5,
• k is an integer of 1 to 3, and
• when k is 2 or 3, n' is optionally variable within the range of 1 to 5 in each occurrence of the --X--(CH.sub.2).sub.n' group,
• with the proviso that there are 8-15 carbon atoms in series between the quinone ring and Y.sup.1,
• or its hydroquinone form,
• or a pharmaceutically acceptable salt thereof,
• and a pharmaceutically acceptable carrier or excipient therefor.

A method for suppressing the production of SRS-A in a mammal in need thereof, which comprises administering to said mammal an effective amount of a compound of the formula:

• ##STR133## wherein R.sup.1 is methyl or methoxy, or the two R.sup.1 groups jointly represent --CH.dbd.CH--CH.dbd.CH--,
• X is --CH.dbd.CH-- or --C.tbd.C--,
• Y.sup.1 is hydrogen, hydroxyl, carboxyl, cyano, C.sub.2-4 alkanoyloxy, benzoyloxy or --COZ in which Z is amino or mono- or di-C.sub.1-4 alkylamino,
• m is zero or an integer of 1 to 3,
• n is zero or an integer of 1 to 10,
• n' is an integer of 1 to 5,
• k is an integer of 1 to 3, and
• when k is 2 or 3, n' is optionally variable within the range of 1 to 5 in each occurrence of the --X--(CH.sub.2).sub.n' group,
• or its hydroquinone form,
• or a pharmaceutically acceptable salt thereof.