# US 4,393,067 A · Nicotinoyl esters for analgesic and anti-inflammatory treatment

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- Number: US 4,393,067 A
- Document ID: US4393067A
- Status: Granted
- Kind: A
- Application number: 06/325,029
- Filed: 1981-11-25
- Granted: 1983-07-12
- Earliest claimed: 1980-01-19
- Assignees: D&D Corporation
- Inventors: Alberto Reiner
- Web page: https://patentgrep.com/patent/US4393067A

## CPC

- C07D 213/80: in position 3
- A61P 3/06: Antihyperlipidemics
- A61P 3/08: for glucose homeostasis (pancreatic hormones A61P5/48)
- C07D 491/04: Ortho-condensed systems
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A61P: SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS

## Abstract

The nicotinic ester of (3-4)-O-isopropylidene pyridixole having the formula: ##STR1## shows analgesic and anti-inflammatory activity.

## Claims

### Claim 1

A method for the treatment of inflammation in a patient in need of such treatment, said method comprising administering to said patient a therapeutically effective amount of the nicotinoyl ester of (3-4)-O-isoproylidene pyridoxine.

### Claim 2

A method for inducing analgesia in a patient in need of such analgesia, said method comprising administering to said patient a therapeutically effective amount of the nicotinoyl ester of (3-4)-O-isopropylidene pyridoxine.

### Claim 3 (depends on 1)

A method according to claim 1, wherein said ester is administered at a daily dosage level of 600 to 1800 mg.

### Claim 4 (depends on 2)

A method according to claim 2 wherein said ester is administered at a daily dosage level of 600 to 1800 mg.

### Claim 5 (depends on 1)

A method according to claim 1 wherein said ester is administered orally or rectally.

### Claim 6 (depends on 2)

A method according to claim 2 wherein said ester is administered orally or rectally.