# US 4,393,065 A · Animal feed and process

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- Number: US 4,393,065 A
- Document ID: US4393065A
- Status: Granted
- Kind: A
- Application number: 06/249,762
- Filed: 1981-04-14
- Granted: 1983-07-12
- Earliest claimed: 1980-06-23
- Assignees: The Upjohn Company
- Inventors: Melvin J. DeGeeter; John M. McCall; Dirk L. Teagarden
- Web page: https://patentgrep.com/patent/US4393065A

## CPC

- C07D 239/48: Two nitrogen atoms
- A23K 20/116: Heterocyclic compounds
- A23K 20/132: containing only one nitrogen as hetero atom
- A23K 20/137: containing two hetero atoms, of which at least one is nitrogen
- A23K 50/30: for swines
- C07D 239/50: Three nitrogen atoms
- C07D 251/18: with nitrogen atoms directly attached to the two other ring carbon atoms, e.g. guanamines
- C07D 251/70: Other substituted melamines
- C07D: HETEROCYCLIC COMPOUNDS (macromolecular compounds C08)
- A23K: FODDER

## Abstract

A process for increasing productivity in healthy animals comprising the administration of a compound of the formula ##STR1## in association with the animal feed water or salt rations. Compositions comprising a compound of the above formula for daily administration or long acting forms are disclosed.

## Claims

### Claim 1

A process for obtaining increased meat, milk, egg or wool production in healthy animals comprising the administration to a healthy animal a long acting composition containing an effective amount of a compound of the formula ##STR6## wherein X is N;
Y is CR.sub.5 ;
R is alkyl of from 1 to 8 carbon atoms, inclusive, including isomeric forms thereof;
R.sub.1 is R or ##STR7## R.sub.2 and R.sub.3 are the same or different and are hydrogen, provided that R.sub.2 and R.sub.3 are not both hydrogen, R, cycloalkyl of from 3 to 8 carbon atoms, inclusive, alkyl substituted cycloalkyl of the formula
--C(CHR.sub.7)n,
alkenyl of from 2 to 8 carbon atoms, inclusive, including isomeric forms thereof, aralkyl wherein
Ar is phenyl or substituted phenyl wherein 1 or 2 hydrogens are replaced with chlorine, fluorine, bromine, iodine, R, --OR, or CF.sub.3, and the substituents can be the same or different, and alkyl is from 1 to 4 carbon atoms, inclusive, including isomeric forms thereof; and P.sub.2 and R.sub.3 taken together with --N< is a heterocyclic moiety of from 3 to 8, inclusive, ring atoms and 1 or 2 hetero atoms selected from the group consisting of nitrogen, oxygen or sulfur or a substituted heterocyclic moiety wherein 0, 1, 2, or 3 of the carbon atoms of the heterocycle are substituted with R;
R.sub.4 is hydrogen, ##STR8## alkenyl of from 2 to 8 carbon atoms, inclusive, including isomeric forms thereof, cycloalkyl of from 3 to 7 carbon atoms, inclusive, or lower acyl wherein acyl is up to and including 5 carbon atoms;
R.sub.5 is hydrogen, R, bromo or chloro;
R.sub.6 is hydrogen, ##STR9## or lower acyl; R.sub.7 is hydrogen or alkyl of from 1 to 5 carbon atoms, inclusive, including isomeric forms thereof;
n is an integer of from 2 to 7, inclusive, said composition being in the form of an implant, bolus, or sterile injectable.

### Claim 2 (depends on 1)

The process of claim 1 wherein the compound is 2,4-diamino-6-piperidinopyrimidine-3-oxide.