# US 4,393,057 A · Pharmaceutical preparations

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- Number: US 4,393,057 A
- Document ID: US4393057A
- Status: Granted
- Kind: A
- Application number: 06/371,400
- Filed: 1982-04-26
- Granted: 1983-07-12
- Earliest claimed: 1980-02-07
- Assignees: Hoffmann-La Roche Inc.
- Inventors: Walter Boguth; Georges Hirth
- Web page: https://patentgrep.com/patent/US4393057A

## CPC

- A61K 9/0019: {Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner (non-active ingredients are additionally classified in A61K47/00)}
- A61K 31/635: having a heterocyclic ring, e.g. sulfadiazine
- A61K 47/10: Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
- A61K: PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES (devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms A61J3/00; chemical aspects of, or use of materials for deodorisation of air, for disinfection or sterilisation, or for bandages, dressings, absorbent pads or surgical articles A61L; soap compositions C11D)

## Abstract

Pharmaceutical preparations containing glycerol alkyl ethers as the solvent.

## Claims

### Claim 1

A pharmaceutical preparation comprising an effective amount of a pharmaceutically active sulphonamide and a solvent containing a glycerol lower-alkyl ether selected from glycerol 1-methyl ether, glycerol 1-ethyl ether, glycerol 1,3-dimethyl ether and glycerol,1,2-dimethyl ether, said glycerol lower-alkyl ether and said solvent being present in an amount sufficient to dissolve said active ingredient.

### Claim 2 (depends on 1)

The preparation of claim 1 wherein said ether is present in said solvent in an amount of at least 50% by volume.

### Claim 3 (depends on 2)

The preparation of claim 2 wherein the glycerol lower-alkyl ether is a glycerol mono(lower-alkyl)ether or a glycerol di(lower-alkyl)ether.

### Claim 4 (depends on 3)

The preparation of claim 3 wherein the glycerol lower-alkyl ether is glycerol,1,2-dimethyl ether, glycerol 1-methyl ether or glycerol 1,3-dimethyl ether.

### Claim 5 (depends on 2)

The preparation of claim 2 wherein the solvent contains 50% to 80% by volume of a glycerol lower-alkyl ether and 20% to 50% by volume of water.

### Claim 6 (depends on 5)

The preparation of claim 5 wherein said solvent contains ethanol.

### Claim 7 (depends on 1)

The preparation of claim 1 wherein the sulphonamide is sulphamethoxazole, and a potentiating amount of trimethoprin is also present in a preparation, and the solvent is glycerol 1-methyl ether.